[A unified digital circuit in ensuring operative monitoring of carbohydrate metabolism in middle, elderly and senile aged people in the conditions of a new coronavirus infection.].

One of the positive aspects of the implementation of laboratory information systems (LIS) in a medical organization, according to the plan of the Federal project of the Ministry of Health of the Russian Federation to create a unified digital circuit in healthcare, is the emergence of the ability to download large amounts of laboratory research data and analyze them. The purpose of the work is to assess the possibility of a unified digital circuit in providing operational monitoring of carbohydrate metabolism in middle-aged, elderly and senile people in the context of COVID-19. The materials used are the primary data of laboratory research results from the LIS «Ariadna.

[Peculiarities of the time of manifestation of a number of diseases in the periods before and after the COVID-19 pandemic according to the data of municipal polyclinics of Sakhalin region.].

The topic of the timing of the manifestation of age-associated diseases (as an indirect indicator of accelerated population aging) after the transfer of COVID-19 remains an urgent area in scientific research. Early targeted diagnosis can significantly reduce the consequences of pathology, in connection with which the features of the manifestation of various nosologies in the post-COVID period were studied. The materials were the accounting and statistical data of the municipal polyclinics of the Sakhalin Region for the pre-COVID (2017-2019) and post-COVID (2022-2023) periods.

[Median age of patients in the projection of the epidemiological indicator.].

At the population level, accelerated aging can manifest itself as an early manifestation of age-associated pathology. Earlier, as an indicator of the order of manifestation of various diseases, we substantiated the age-specific incidence index (ASII), which is the ratio of the primary incidence rate among people over working age to the same indicator for the entire adult population. At the same time, it seems necessary to explain the mathematical relationship between median age and ASII.

[Fibrophysematous lung changes and microbiota changes in senile persons.].

Research on the condition of the lungs in senile people is an urgent task. This is due to the fact that degenerative or age-associated changes in the respiratory system play an important role in the formation of senile asthenia syndrome and a decrease in the age-related viability of the body as a whole. CT-scans of patients aged 80-90 years were analyzed (n=31).

[The medical significance of loneliness and social isolation in old age (literature review).].

Communication is considered as one of the basic human needs. For a long time, loneliness and social isolation were mainly considered as a psychosocial problem. However, in the recent years, there has been increasing evidence of the possible impact of loneliness and social isolation on the development and clinical course of somatic diseases.

[Analysis of age-related incidence (by circulation) of age-associated pathology in 2018-2023 on the example of the municipal polyclinic of Saint-Petersburg.].

From the age of 25-30, the likelihood of developing pathological processes associated with aging begins to increase. Age-associated diseases (AAD) are a heterogeneous group of pathologies that are more likely to develop as they age. Clinically, the early development of AAD is identical to premature aging with all the ensuing consequences.

[Economic index - predictor of premature aging.].

It is widely known that in economically developed countries there is an increase in the proportion of older people. However, the problem of the influence of territorial features of economic development on the rate of population aging is not sufficiently covered. The goal was to study the impact of economic development indicators (EDI) on the processes of premature aging of the population.

The Influence of Adiponectin on Transport of Low-Density Lipoproteins through Human Endothelial Cell Monolayer In Vitro.

The influence of adiponectin, a protein secreted by adipocytes, on the activation of transendothelial LDL transport, the initial event of atherogenesis, was studied. The addition of adiponectin to the cultured endothelial hybridoma EA.hy926 cells did not affect both basal and TNF-stimulated transendothelial transport of LDL.

[Accelerated population aging as a consequence of the COVID-19 pandemic (review).].

The COVID-19 pandemic has had an impact on many aspects of human life. One of the consequences of the coronavirus period was the accelerated aging of the population. This fact is confirmed in the works of many scientists.

[Pathogenetic and chemical-laboratory aspects of age-associated vascular diseases of older and senile persons (review).].

Cardiovascular diseases, including atheroscleroscoronary and cerebral arteries, are an important medical and social problem of the population, especially among the elderly and seniors. The proportion of older persons is about 80% among deaths from complications of atherosclerosis and over 60% among all detected cases of myocardial infarction in the Russian Federation. Age changes in the body negatively affect the course of the disease.

[Prognostic potential of inflammatory factors in older patients diagnosed with COVID-19.].

The COVID-19 pandemic requires a quick and accurate diagnosis and assessment of the condition of patients, correctly chosen by the tactics of treatment and prediction of the course of the disease, especially in older patients. The most promising direction is the study of the potential of inflammatory factors among people over 60 years of age. This paper analyzed serum level characteristics of analytes such as C-reactive protein, procalcitonin, IL-6, troponin, ferritin and brain natriuretic peptide.

[Features of the coefficient of variation of hematological indicators in persons of middle, elderly and senile age with pneumonia.].

Pneumonia is the leading mortality rate among all infectious diseases. It has been established that the reliable risk group for morbidity and mortality from this nosology includes persons over 60 years of age, and with age the severity of the disease only increases. According to literary data, one of the reasons for the decline in adaptation capabilities of older persons is the phenomenon of «age desinhronosis», which manifests itself in significant fluctuations in the parameters of the internal environment of the body.

[Age and nosological structure of ophthalmological diseases of patients of the ophthalmological center of Saint-Petersburg in 2015-2019.].

About 1,3 billion people live on our planet with visual disorders such as cataract and glaucoma, the prevalence of which is significantly higher in the elderlypopulation. Eye diseases remain a global medical, social and economic problem, associated with both the progression of the disease to blindness and the lack of pathogenetic therapy methods. A retrospective analysis of the long-term dynamics and structure of cases of ophthalmological diseases of patients treated in a large multidisciplinary hospital was carried out.

[Features of the picture of blood cells in elderly persons with primary open-angle glaucoma.].

Around 1,3 billion people live worldwide with visual analyzer disorders such as glaucoma and cataract. These diseases are particularly common among the elderly. From glaucoma every year 10 million people completely lose vision, one of the factors of which is untimely diagnosis.

[Laboratory predictors of glaucoma in patients with middle and old age - a tool to improve the quality of life (literature review).].

There are about 1,3 billion people worldwide with visual disorders such as cataract and glaucoma, the prevalence of which is significantly higher in elder persons. Eye diseases remain a global medical, social and economic problem, associated with both the progression of the disease up to blindness and the lack of pathogenetic therapy methods. Timely detection of pathology is secondary prevention of glaucoma.