Mortality predictors in acute myocardial infarction: results from a single-center study in Saudi Arabia.

Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide. Risk factors of mortality in patients with AMI have been widely investigated, identifying older age and heart failure as common contributors. This study aimed to determine risk factors and explore predictors associated with higher mortality among patients with AMI.

Functional Medicine in Nursing.

Functional medicine is a patient-centered approach that seeks to address the underlying causes of disease rather than focusing on managing the symptoms. This article explains the core principles of functional medicine and explores the potential for nurses to learn and incorporate functional medicine into their practice. By adopting a functional medicine approach, nurses can promote a more personalized and collaborative health care environment that can improve patient outcomes and empower patients to take an active role in their own health journey.

Revisiting Amputation Rates in High-Pressure Injection Injuries.

Purpose: High-pressure injection injuries are a rare, and potentially serious, trauma that has historically been associated with high-amputation rates. This study aimed to assess the amputation rates, materials involved, and outcomes at a single institution.

Methods: A retrospective analysis of 53 cases at a level-1 trauma center in South Central Texas between 2007 and 2023 was conducted.

Evaluation of a Large Language Model's Ability to Assist in an Orthopedic Hand Clinic.

Background: Advancements in artificial intelligence technology, such as OpenAI's large language model, ChatGPT, could transform medicine through applications in a clinical setting. This study aimed to assess the utility of ChatGPT as a clinical assistant in an orthopedic hand clinic.

Methods: Nine clinical vignettes, describing various common and uncommon hand pathologies, were constructed and reviewed by 4 fellowship-trained orthopedic hand surgeons and an orthopedic resident.

Trace Mineral Supplementation for Beef Cows: Dry Range Environment.

Range mineral supplementation is based on providing trace minerals not adequately provided from grazed forage in meeting beef cattle needs throughout life cycle stages. Supplementation programs should be developed with consideration of ranch production goals, economics, and practicality for implementation. Factors such as season of grazing, forage analysis, water analysis including antagonistic elements, and measured animal responses are used in mineral supplement formulation for range cattle.

Reducing Tourniquet Pressures in Hand Surgery: Are Lower Pressures as Effective?

 Pneumatic tourniquets are widely used in hand surgery. Elevated pressures can be associated with complications, and thus, guidelines based on patient-specific tourniquet pressures have been recommended. The primary aim of this study was to determine whether lower tourniquet values based on systolic blood pressure (SBP) could be effectively applied in upper extremity surgery.

30-Day Postoperative Complications After Surgical Treatment of Proximal Humerus Fractures: Reverse Total Shoulder Arthroplasty Versus Hemiarthroplasty.

Introduction: The purpose of this study was to evaluate risk factors associated with complications after reverse total shoulder arthroplasty (TSA) and hemiarthroplasty for the treatment of proximal humerus fractures.

Methods: A retrospective review of the American College of Surgeons National Surgical Quality Improvement Program database was conducted. Current Procedural Terminology codes were used to identify patients treated for proximal humerus fracture with reverse TSA or hemiarthroplasty between 2005 and 2018.

Thermal Debridement in the Management of Low Grade Scapholunate Ligament Tears.

Low grade scapholunate interosseous ligament (SLIL) tears are often managed with mechanical or thermal arthroscopic debridement, although this remains controversial. This study aimed to assess the short-term outcomes of thermal debride- ment of low-grade SLIL tears. Patients with low grade SLIL tears who underwent arthroscopic thermal debridement between 2010 and 2017 were identified and divided into two groups: isolated thermal debridement and concomitant pro- cedures.

The effect of age on risk of retear after rotator cuff repair: a systematic review and meta-analysis.

Hypothesis: The purpose of this study was to perform a systematic review and meta-analysis to determine the effect of age on rotator cuff repair failure. The hypothesis of this study was that increased patient age would lead to a higher rate of retears and/or repair failures after rotator cuff repair.

Methods: We conducted a systematic review and meta-analysis of level I and II studies evaluating patients undergoing rotator cuff repair that also included an imaging assessment of the structural integrity of the repair.

Preoperative glenoid considerations for shoulder arthroplasty: a review.

Preoperative assessment of the glenoid in the setting of shoulder arthroplasty is critical to account for variations in glenoid morphology, wear, version, inclination, and glenohumeral subluxation.Three-dimensional computed tomography (3D CT) scan assessment of the morphology of glenoid erosion allows for a more accurate surgical decision-making process to correct deformity and restore the joint line.Newer technology has brought forth computer-assisted software for glenoid planning in shoulder arthroplasty and patient-specific instrumentation.

Surgically relevant anatomy of the axillary and radial nerves in relation to the latissimus dorsi tendon in variable shoulder positions: A cadaveric study.

Background: The purpose of this study was to define the relationship of the axillary and radial nerves, particularly how these are affected with changing arm position.

Methods: Twenty cadaveric shoulders were dissected, identifying the axillary and radial nerves. Distances between the latissimus dorsi tendon and these nerves were recorded in different shoulder positions.

Use of an Extensile Posterior Approach to the Elbow Joint: Early Results of the Anconeus Approach.

Commonly used surgical approaches to the elbow typically limit the surgeon to either medial or lateral exposure, can provide visualization limited by an intact radial head, and may not be extensile. We describe the use of a well recognized, but uncommonly used, extensile approach to the medial and lateral compartments of the elbow joint. This approach provides access to address pathology of the proximal radius, ulna, and the distal humerus and can be made extensile both proximally and distally.

Timing and Risk Factors for Venous Thromboembolism After Rotator Cuff Repair in the 30-Day Perioperative Period.

Purpose: To analyze the American College of Surgeons National Surgical Quality Improvement Program database to evaluate the incidence of deep venous thrombosis and pulmonary embolism in patients undergoing rotator cuff repair surgery. In addition, we aim to identify risk factors associated with the development of thromboembolic events following rotator cuff repair.

Methods: A retrospective review of the American College of Surgeons National Surgical Quality Improvement Program database was performed.

Buprenorphine and Naloxone Versus Buprenorphine for Opioid Use Disorder in Pregnancy: A Cohort Study.

Objective: To compare maternal and fetal outcomes among dyads prescribed buprenorphine and naloxone or buprenorphine during pregnancy.

Methods: Retrospective cohort study of patients with opioid use disorder obtaining care in a comprehensive, perinatal program. Patients utilized medication for opioid use disorder: a buprenorphine and naloxone combination product or buprenorphine monotherapy.

Innervation of the subscapularis: an anatomic study.

Background: Successful healing of the subscapularis during anatomic total shoulder arthroplasty surgery is critical to optimize functional outcomes and avoid complications. The purpose of this study was to examine the upper and lower subscapularis nerve insertion in relation to the musculotendinous junction to estimate the risk of nerve injury. Our hypothesis was that arm position changes the risks to these nerves when exposing the anterior glenoid.

Cohort analysis of desmopressin effect on hematoma expansion in patients with spontaneous intracerebral hemorrhage and documented pre-ictus antiplatelet use.

Antiplatelet therapy at the time of spontaneous intracerebral hemorrhage (sICH) may increase risk for hemorrhage expansion and mortality. Current guidelines recommend considering a single dose of desmopressin in sICH associated with cyclooxygenase-1 inhibitors or adenosine diphosphate receptor inhibitors. Adult subjects with sICH and concomitant antiplatelet therapy admitted to a large, tertiary care center were included.

A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice.

The type 2 iodothyronine-deiodinase (D2) enzyme converts T4 to T3, and mice deficient in this enzyme [D2 knockout (D2KO) mice] have decreased T3 derived from T4 in skeletal muscle despite normal circulating T3 levels. Because slow skeletal muscle is particularly susceptible to changes in T3 levels, we expected D2 inactivation to result in more pronounced slow-muscle characteristics in the soleus muscle, mirroring hypothyroidism. However, ex vivo studies of D2KO soleus revealed higher rates of twitch contraction and relaxation and reduced resistance to fatigue.

Bactericidal efficacy of hydrogen peroxide on .

Objectives: The purpose of this study was to examine the bactericidal efficacy of hydrogen peroxide (HO) on (). We hypothesize that HO reduces the bacterial burden of .

Methods: The effect of HO was assessed by testing bactericidal effect, time course analysis, growth inhibition, and minimum bactericidal concentration.

Escape from temporal-integration masking: the roles of visible persistence and input filtering.

A brief target embedded in—and coterminating with—a noise mask is identified easily when the duration of the mask is long but not when it is short (Di Lollo, 1980; inverse-duration effect). Identification has been said to be mediated by the visible persistence of the target, which outlasted that of the mask. We tested an alternative account based on input filtering triggered by the onset and offset of the target, relative to those of the mask, without recourse to visible persistence.

Motorcyclist's lane position as a factor in right-of-way violation collisions: a driving simulator study.

A driver turning left and failing to notice an oncoming motorcyclist until too late is the most common cause of motorcycle collisions. Consequently, much previous research has focused on motorcycle properties, such as size, shape, and color to explain its inconspicuousness. However, collision statistics remain largely unchanged, suggesting that the issue may not be related solely to the motorcycle's static properties.

ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair.

DNA replication fork stalling or collapse that arises from endogenous damage poses a serious threat to genome stability, but cells invoke an intricate signaling cascade referred to as the DNA damage response (DDR) to prevent such damage. The gene product ataxia telangiectasia and Rad3-related (ATR) responds primarily to replication stress by regulating cell cycle checkpoint control, yet it's role in DNA repair, particularly homologous recombination (HR), remains unclear. This is of particular interest since HR is one way in which replication restart can occur in the presence of a stalled or collapsed fork.

Corticosteroids increase glutamine utilization in human splanchnic bed.

Glutamine is the most abundant amino acid in the body and is extensively taken up in gut and liver in healthy humans. To determine whether glucocorticosteroids alter splanchnic glutamine metabolism, the effect of prednisone was assessed in healthy volunteers using isotope tracer methods. Two groups of healthy adults received 5-h intravenous infusions of l-[1-(14)C]leucine and l-[(2)H(5)]glutamine, along with q.

Evidence for accelerated rates of glutathione utilization and glutathione depletion in adolescents with poorly controlled type 1 diabetes.

Depletion of glutathione, an important antioxidant present in red cells, has been reported in type 1 diabetes, but the mechanism of this depletion has not been fully characterized. Glutathione depletion can occur through decreased synthesis, increased utilization, or a combination of both. To address this issue, 5-h infusions of l-[3,3-(2)H(2)]cysteine were performed in 16 diabetic adolescents divided into a well-controlled and a poorly controlled group and in eight healthy nondiabetic teenagers as control subjects (HbA(1c) 6.

Effect of lifestyle changes on whole-body protein turnover in obese adolescents.

Objective: To investigate the effect of lifestyle changes on whole-body protein turnover (WBPT) in obese adolescents.

Design/methods: Randomized and controlled nonpharmacological intervention study of WBPT in obese adolescents using stable isotope dilution techniques.

Subjects And Measurements: We studied a total of 21 adolescents (11 boys and 10 girls, matched for their pubertal status) of which 15 were obese (age=15.

Synergistic effects of testosterone and growth hormone on protein metabolism and body composition in prepubertal boys.

During human puberty there is a substantial increase in growth hormone (GH) and sex steroidal hormone concentrations, as well as in GH production rates and insulin-like growth factor-I (IGF-I) These studies were designed to investigate some of the interactions of testosterone (T) and GH in the metabolic changes of puberty. Ten boys with severe GH deficiency (GHD) were studied (mean age, 12.5 +/- 0.