EFFECT OF FOLLOW-UP OF ASTHMATIC CHILDREN IN PNEUMOPEDIATRICS ON DISEASE CONTROL.

Introduction: The pneumopediatrics consultation started at CHU-MEL in 2018; follow-up of asthmatic children is a major focus.

Objective: To assess the impact of follow-up on asthma disease control.

Method: This was a prospective cohort study with descriptive and analytical aims from October 2019 to October 2021.

IgG acquisition against PfEMP1 PF11_0521 domain cassette DC13, DBLβ3_D4 domain, and peptides located within these constructs in children with cerebral malaria.

The Plasmodium falciparum erythrocyte-membrane-protein-1 (PF3D7_1150400/PF11_0521) contains both domain cassette DC13 and DBLβ3 domain binding to EPCR and ICAM-1 receptors, respectively. This type of PfEMP1 proteins with dual binding specificity mediate specific interactions with brain micro-vessels endothelium leading to the development of cerebral malaria (CM). Using plasma collected from children at time of hospital admission and after 30 days, we study an acquisition of IgG response to PF3D7_1150400/PF11_0521 DC13 and DBLβ3_D4 recombinant constructs, and five peptides located within these constructs, specifically in DBLα1.

[Mite sensitization in children followed for respiratory allergy in a tropical African environment in Cotonou, Benin].

Introduction: In tropical Africa, allergies are not well documented. The objective of this work was to evaluate, by two methods, the sensitization to mites in children followed for respiratory allergy.

Methods: Skin prick-test and IgE assay by REAST test with 3 mites: Dermatophagoides pteronyssinus (D.

Proteomic analysis of Plasmodium falciparum parasites from patients with cerebral and uncomplicated malaria.

Plasmodium falciparum is responsible of severe malaria, including cerebral malaria (CM). During its intra-erythrocytic maturation, parasite-derived proteins are expressed, exported and presented at the infected erythrocyte membrane. To identify new CM-specific parasite membrane proteins, we conducted a mass spectrometry-based proteomic study and compared the protein expression profiles between 9 CM and 10 uncomplicated malaria (UM) samples.

Immunoglobulin response to Plasmodium falciparum RESA proteins in uncomplicated and severe malaria.

Background: The three members of the ring-infected erythrocyte surface antigen (RESA) proteins family share high sequence homologies, which impair the detection and assignment to one or another protein of some pathogenic processes inherent to Plasmodium falciparum malaria. The present study was intended to determine if the antibody and inflammatory responses of children living in a malaria-endemic area varied depending on the RESA-1, RESA-2 or RESA-3 proteins and the severity of the disease, two groups of severe and uncomplicated malaria cases being considered.

Methods: Two synthetic peptides representing predicted B cell epitopes were designed per RESA protein, all located outside of the 3' and 5' repetition blocks, in order to allow an antibody detection specific of each member of the family.

High plasma levels of soluble endothelial protein C receptor are associated with increased mortality among children with cerebral malaria in Benin.

Loss of endothelial protein C receptor (EPCR) occurs at the sites of Plasmodium falciparum-infected erythrocyte sequestration in patients with or who died from cerebral malaria. In children presenting with different clinical syndromes of malaria, we assessed the relationships between endogenous plasma soluble EPCR (sEPCR) levels and clinical presentation or mortality. After adjustment for age, for treatment before admission, and for a known genetic factor, sEPCR level at admission was positively associated with cerebral malaria (P = .

Cytoadherence phenotype of Plasmodium falciparum-infected erythrocytes is associated with specific pfemp-1 expression in parasites from children with cerebral malaria.

Background: Cytoadherence of Plasmodium falciparum-infected erythrocytes (IEs) in deep microvasculature endothelia plays a major role in the pathogenesis of cerebral malaria (CM). This biological process is thought to be mediated by P. falciparum erythrocyte membrane protein-1 (PfEMP-1) and human receptors such as CD36 and ICAM-1.

[Limbs and forarms agenesy associated in infant: an observation].

Growth disorders are frequent in human and are represented mainly by malformation recognizable pre and postnatally. These malformations contribute to infant morbidity and mortality. They could occur in any organ and system.

Autosomal dominant polycystic kidney disease in University Clinic of Nephrology and Haemodialysis of Cotonou: clinical and genetical findings.

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, but poorly studied in Africa. Its frequency in the University Clinic of Nephrology and Hemodialysis of Cotonou during the ten last years was 7 cases per year with a hospital prevalence estimated at 18 per 1000. The mean age of patients was 47.

[Profile of HIV-infected children at the National University Hospital of Cotonou (CNHU)].

Objective: To describe the profile of HIV-infected children.

Methods: This was a cross-sectional, descriptive and analytic study involving 317 infected children, monitored from January 1st, 2002 to July 31st, 2010 at CNHU of Cotonou.

Results: The average age was 89.

[Drug eruptions in children in Cotonou, Benin].

Introduction: The aim of this study was to investigate the epidemiological aspects of drug eruptions in children in hospital area in Cotonou.

Patients And Method: A retrospective study was carried out in the Department of Dermatology of Cotonou (Benin) from 1998 to 2009. All cases of drug eruption occurred, during the study period, in children under 16 years old were selected for the study.

Possible association of the Plasmodium falciparum T1526C resa2 gene mutation with severe malaria.

Background: Plasmodium falciparum exports proteins that remodel the erythrocyte membrane. One such protein, called Pf155/RESA (RESA1) contributes to parasite fitness, optimizing parasite survival during febrile episodes. Resa1 gene is a member of a small family comprising three highly related genes.

Paediatric tuberculosis at the national teaching hospital CNHU-HKM of Cotonou, Benin: a retrospective study.

Unlabelled: BACKGROIUND: Tuberculosis (TB) is a public health problem. Knowing its patterns could help address it more efficiently.

Objective: To determine the hospital incidence, presentation, management, and outcome of TB in our setting.

[Pleural effusion in children at the National Hospital Center and University of Cotonou: epidemiological, clinical and therapeutic aspects].

Aim: To study the epidemiologic, clinic, biologic and therapeutics aspects of pleural effusion at National university healty center (CNHU) of Cotonou.

Method: From January 2004 to December 2008, we have conduct a retrospective study in the pediatric service of Cotonou’s CNHU. 15 children less than 5 years old were included in the study.