Cytocompatible Hyperbranched Polyesters Capable of Altering the Ca Signaling in Neuronal Cells In Vitro.

Synthetic hyperbranched polyesters with potential therapeutic properties were synthesized using the bifunctional polyethylene glycol or PEG with different molecular weights, ca., 4000, 6000, and 20,000 g/mol, and the trifunctional -aconitic acid or TAA. During polycondensation, a fixed amount of PEG was allowed to react with varying amounts of TAA (1:1 and 1:3) to control the branching extents.

Synthesis of Exfoliated Ni(OH) Nanosheets and AgNPs-Embedded Functionalized Polyindole-Based Trinary Hybrid Microspheres: A Z-Scheme Photocatalyst for the Sunlight-Driven Degradation of Organic Pollutants with Enhanced Antibacterial Efficacy.

Advancing a facile one-pot synthetic approach for the fabrication of a hybrid heterojunction photocatalyst remains a significant challenge in research pursuits. Herein, a microsphere-like trinary hybrid nanocomposite has been synthesized (NH/PIn/MAA/Ag). It comprises exfoliated single- and a few-layered Ni(OH) (NH nanosheets), mercaptoacetate-functionalized polyindole (PIn/MAA), and Ag nanoparticles (AgNPs) through an approach.

Chemical modification of β-cyclodextrin towards hydrogel formation.

β-CD is a cyclic oligosaccharide, which has trunked cone like structure. The unique structure makes it efficient for numerous applications. Though, the native β-CD has many issues like low solubility, absence of sufficient functionalities and lower complexation ability with guest molecules.

Chitosan based titanium and iron oxide hybrid bio-polymeric nanocomposites as potential corrosion inhibitor for mild steel in acidic medium.

Biopolymer chitosan (CS), chitosan grafted acrylamide based titanium dioxide (CS-g-PAM/TiO) and magnetite (CS-g-PAM/FeO) hybrid nanocomposites have been synthesized through free radical graft co-polymerization and successfully validated as corrosion inhibitors for mild steel in 15 % HCl solution. The synthesized compounds have been characterized through FTIR, APC, XRD and TEM. The thermal stability of the nanocomposites was established by TGA.

β-Cyclodextrin-Based Ultrahigh Stretchable, Flexible, Electro- and Pressure-Responsive, Adhesive, Transparent Hydrogel as Motion Sensor.

In the present work, a multiple-stimuli-responsive hydrogel has been synthesized via polymerization of acrylamide (AAm) and -hydroxy methyl acrylamide (HMAm) on β-cyclodextrin (β-CD). The synthesized hydrogel β-CD--(pAAm/pHMAm) exhibited various striking features like ultrahigh stretchability (>6000%), flexibility, stab resistivity, self-recoverability, electroresponsiveness, pressure-responsiveness, adhesiveness, and high transparency (>90%). Besides, the hydrogel has demonstrated enhanced biocompatibility, UV resistance, and thermoresponsive shape memory behaviors.

Poly(-vinyl imidazole) Cross-Linked β-Cyclodextrin Hydrogel for Rapid Hemostasis in Severe Renal Arterial Hemorrhagic Model.

A unique facile process has been adopted for fast assembly of a poly(-vinyl imidazole) cross-linked β-cyclodextrin hydrogel through microwave-assisted free radical polymerization, using ,'-methylenebis(acrylamide) cross-linker. The copolymer possesses positive surface charge, one of the characteristic properties of an ideal hemostatic hydrogel. The functionalized imidazole-based hydrogel demonstrates rapid, superior blood coagulation kinetics under and conditions.

Dextran based amphiphilic self-assembled biopolymeric macromolecule synthesized via RAFT polymerization as indomethacin carrier.

This work demonstrates a facile pathway to develop a biopolymer based amphiphilic macromolecule through reversible addition-fragmentation chain transfer (RAFT) polymerization, using dextran (a biopolymer) as starting material. Also, a new hydrophobic monomer [2-methyl-acrylic acid 1-benzyl-1H-[1,2,3] triazol-4-ylmethyl ester (MABTE)] has been synthesized using methacrylic acid via "click" approach. The resultant copolymer displays controlled radical polymerization characteristics: narrow polydispersity (Ð) and controlled molecular weight as obtained through advanced polymer chromatography (APC) analysis.

Dual Functionalized Injectable Hybrid Extracellular Matrix Hydrogel for Burn Wounds.

Low strength and rapid biodegradability of acellular dermal matrix (ADM) restrict its wider clinical application as a rapid cell delivery platform for management of burn wounds. Herein, the extracted ADM was modified by a dual cross-linking approach with ionic crosslinking using chitosan and covalent cross-linking using an iodine-modified 2,5-dihydro-2,5-dimethoxy-furan cross-linker, termed as CsADM-Cl. In addition, inherent growth factors and cytokines were found to be preserved in CsADM-Cl, irrespective of ionic/covalent crosslinking.

Crosslinked chitosan embedded TiO NPs and carbon dots-based nanocomposite: An excellent photocatalyst under sunlight irradiation.

Herein, a new hybrid nanocomposite, comprising of titania nanoparticles (TiO NPs) and carbon dots (CDs) deposited polyvinyl imidazole crosslinked chitosan [cl-Ch-p(VI)/TiONPs-CDs] has been developed. The nanocomposite has been synthesised by in-situ deposition of TiO NPs and CDs onto the surface of the copolymer under microwave irradiation. To the best of our knowledge, this in-situ approach has effectively been applied for the first time to fabricate green fluorescent CDs from sugar cane juice at moderate temperature (75 °C) under microwave irradiation.

Development of a Thermoresponsive Polymeric Composite Film Using Cross-Linked β-Cyclodextrin Embedded with Carbon Quantum Dots as a Transdermal Drug Carrier.

Polymeric nanocomposite films are used as promising transdermal drug carriers because of the improved patient compliance, easy application on skin, and noninvasiveness. A thermoresponsive polymeric composite film has been developed here through the deposition of carbon quantum dots (CQDs) on functionalized β-cyclodextrin (β-CD). The composite has been developed by grafting of poly(-vinyl caprolactam) on β-CD, followed by cross-linking of diethylene glycol dimethacrylate and subsequent deposition of CQDs.

Novel nanocomposite derived from ZnO/CdS QDs embedded crosslinked chitosan: An efficient photocatalyst and effective antibacterial agent.

A novel nanocomposite (cl-Ch-pMAc@ZnO/CdSQDs) has been developed under microwave irradiation via fabrication of ZnO/CdS quantum dots on anionically functionalized chitosan [i.e. poly (methacrylic acid) crosslinked chitosan (cl-Ch-pMAc) in the presence of diethylene glycol dimethacrylate (DEGDMA) crosslinker].

Removal of toxic pollutants from aqueous media using poly (vinyl imidazole) crosslinked chitosan synthesised through microwave assisted technique.

Water contamination owing to the presence of toxic organic chemicals/heavy metals are considered to be one of the serious global environmental issues. Various advanced polymeric materials have been developed and used for the separation/removal of these contaminants. To consider the afore-mentioned problem, recently in authors' laboratory, an efficient biopolymeric adsorbent has been prepared using poly (vinyl imidazole) crosslinked chitosan (cl-Ch-pVI) through a simple microwave-assisted free radical polymerization technique.

Graft copolymeric flocculant using functionalized starch towards treatment of blast furnace effluent.

Herein, a novel binary graft copolymeric flocculant [St-g-(PAAm-co-PMETAC)] has been developed using starch, polyacrylamide (PAAm) and poly (2-methacryloyloxy ethyl trimethyl ammonium chloride) (PMETAC). The copolymer has been synthesised by grafting of PAAm and PMETAC chains on starch backbone using free radical polymerization. FTIR and H NMR spectral analyses have been used for structural confirmation of developed copolymer.

Amphiphilic graft copolymeric micelle using dextrin and poly (N-vinyl caprolactam) via RAFT polymerization: Development and application.

Dextrin and poly (N-vinyl caprolactam) based amphiphilic graft copolymer has recently been developed using RAFT polymerization. The prepared graft copolymer has been characterized in details using FTIR and H NMR spectral analyses, GPC, TGA, FESEM, TEM and DLS analyses. GPC analysis results indicate that the polymerization is controlled, while the LCST value of the copolymer suggests that the synthesized copolymer demonstrates sol-gel behaviour on applying temperature.

Synthesis of triblock copolymeric micelle based on poly (ethylene glycol) and poly (vinyl acetate) through reversible addition-fragmentation chain transfer polymerization.

Hypothesis: Polymeric micelles are fabricated by the self-aggregation of amphiphilic polymers in aqueous medium. Amphiphilic block copolymers consist of hydrophobic and hydrophilic blocks. The hydrophilic blocks form corona, while hydrophobic blocks produce core of the micelle.

In Situ Silver Nanowire Deposited Cross-Linked Carboxymethyl Cellulose: A Potential Transdermal Anticancer Drug Carrier.

Recently, a novel biopolymeric nanocomposite hydrogel comprised of in situ formed silver nanowires (AgNWs) deposited chemically cross-linked carboxymethyl cellulose (CMC) has been developed, which demonstrates superior efficacy as anticancer drug-curcumin carrier. The cross-linked polymer has been prepared by grafting poly [2-(methacryloyloxy) ethyl trimethylammonium chloride] on CMC using diethylene glycol dimethacrylate cross-linker. The nanocomposite hydrogel has the capability to encapsulate both hydrophobic/hydrophilic transdermal drugs.

Oleoyl-Chitosan-Based Nanofiber Mats Impregnated with Amniotic Membrane Derived Stem Cells for Accelerated Full-Thickness Excisional Wound Healing.

Wound healing management is a major challenge for critical full-thickness skin wounds. Development of nanofibrous scaffolds with tunable wettability, degradation, and biocompatibility are highly desirable. Herein, we demonstrated synthesis of oleoyl chitosan (OC) by grafting monounsaturated fatty acid residue, C oleoyl chain, to the backbone of chitosan molecule and blending with gelatin to form the nanofiber mats.

Biocompatible nanogel derived from functionalized dextrin for targeted delivery of doxorubicin hydrochloride to MG 63 cancer cells.

The present article demonstrates the targeted delivery of doxorubicin hydrochloride to human osteosarcoma cancer cell lines (MG 63) using functionalized dextrin based crosslinked, pH responsive and biocompatible nanogel. The nanogel has been prepared through Michael-type addition reaction using dextrin (Dxt), N, N'-methylene bisacrylamide (MBA, as crosslinker), acrylic acid (AA, as monomer) and potassium persulfate (KPS, as initiator). The structure, composition, morphology of the nanogel have been explored using FTIR and H NMR spectroscopy, XRD, TGA, DSC, CHN and AFM analyses.

Amphiphilic copolymer derived from tamarind gum and poly (methyl methacrylate) via ATRP towards selective removal of toxic dyes.

Herein an amphiphilic graft copolymer has been synthesized from tamarind gum and poly (methyl methacrylate) (g-TKP/pMMA) using atom transfer radical polymerization (ATRP) in presence of CuBr/bpy catalyst. Structural and surface properties of the copolymer have been investigated using H NMR and FTIR spectra, DLS, TGA and FESEM analyses. The controlled and living nature of polymerization reaction has been explored using GPC analysis, while the gel characteristics of the copolymer has been analysed by rheological study.