Docking and simulation studies on cyclin D/CDK4 complex for targeting cell cycle arrest in cancer using flavanone and its congener.

Flavanone compounds are naturally occurring phytochemicals present in most of citrus fruits reported to be a potential anticancer moiety as it majorly participates in the inhibition of the cell cycle, apoptosis, and angiogenesis. Because of poor bioavailability, natural flavanones were not used as therapeutic targets so flavanone congeners were prepared by modifying at B-functional group using compound libraries such as PubChem Database. Cyclin-dependent kinase is primarily activating the cell cycle and potentiating the M phase, in order to control the cell cycle in cancer cyclin-dependent pathway was targeted and potential cyclin D/CDK4 receptor protein was retrieved from Protein Data Bank (PDBID:2W9Z).

Molecular Docking and Simulation Studies of Flavanone and its Derived Compounds on PI3K-AKT Pathway Targeting against Cancer.

Background: Flavanone compounds and their related derivatives are reported in controlling cell cycle, angiogenesis, and metastasis. Phosphoinositide 3-kinases is a major drug target.

Methods: Crystalize structure of Phosphoinositide 3-kinases-Akt complex obtained from Protein Data Bank (PDBID: 3CQW) was selected as receptor protein and the binding site has been identified with PDBSum Database.

Prevalence of Haller's Cells: A Panoramic Study.

Context: Haller's cells or infraorbital ethmoid cells refer to the ethmoidal pneumatization of the superior aspect of the maxillary sinus, and floor of the orbit can be seen on panoramic radiographs. They appear as well-defined, round-, oval-, or teardrop-shaped radiolucencies with smooth corticated or noncorticated borders.

Aims And Objective: To determine the prevalence and scrutinize the characteristics of Haller's cells on panoramic radiographs.

Sex determination in forensic identification, a review.

Forensic odontology is the application of dental principles to legal issues. It is an investigative aspect of dentistry that analyzes dental evidence for human identification. Sex determination is a subdivision of forensic odontology, and it is important especially when information relating to the deceased is unavailable.

A radiographic survey of agenesis of the third molar: A panoramic study.

Purpose: It is a well-known fact that nature tries to eliminate what is not in use. Because of this, the number of certain teeth which are no longer necessary for function are either getting increasingly impacted or are not developing at all. This is especially the case where third molars are concerned.