Evaluation of ameliorative effect of curcumin on imidacloprid-induced male reproductive toxicity in wistar rats.

This study was undertaken to investigate the toxic effects of imidacloprid (IM) on male reproductive system and ameliorative effect of curcumin (CMN) in male Wistar rats. For this purpose, IM (45 and 90 mg/kg, body weight) and CMN (100 mg/kg, body weight) were administered orally to the rats either alone or in combinations for a period of 28 days. At the end of experiment, male reproductive toxicity parameters (total sperm count and sperm abnormalities), testosterone level, steroidal enzymatic activity [3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-HSD], and oxidative stress indicators were estimated in testis and plasma.

Evaluation of imidacloprid-induced neurotoxicity in male rats: a protective effect of curcumin.

The present study was carried out to evaluate the neurotoxic effect and biochemical alteration as a result of imidacloprid (IMI) exposure and potential protective role of curcumin (Cur) against it in rats. Rats were administered with IMI (45 and 90 mg/kg body weight; orally) and Cur (100 mg/kg body weight; orally) alone and in combinations for the period of 28 days. Significant decrease in spontaneous locomotor activity (SLA) and pain threshold were observed in animals treated with the IMI, while the effect was attenuated by the Cur co-treatment.