Predictors of Premature Ventricular Contractions Development in Patients With SARS-CoV-2 Infection.

Background: Epidemiological studies have demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients often develop atrial fibrillation, premature ventricular contractions (PVCs), and conduction disorders. The manifestation of ventricular cardiac arrhythmias accentuates the risk of sudden cardiac death.

Methods: A retrospective study was conducted on the cohort of 1,614 patients admitted for coronavirus disease 2019 (COVID-19).

Significance of Hypoalbuminemia in the Development of Thromboembolic Complications in Severe Cases of SARS-CoV-2 Coronavirus Infection.

Background: The course of coronavirus disease 2019 (COVID-19) is associated with the progression of a wide range of complications, among which thrombosis and thromboembolism are of particular importance. The significance of hypoalbuminemia in the development of thromboembolic complications (TECs) in patients with a severe course of COVID-19 is currently under active discussion. The objective of our study was to evaluate the significance of hypoalbuminemia in the development of TECs in patients with severe SARS-CoV-2 coronavirus infection.

Model-Based Assessment of the Reference Values of CAVI in Healthy Russian Population and Benchmarking With CAVI0.

Background: Cardio-ankle vascular index (CAVI) and its modified version (CAVI0) are promising non-invasive markers of arterial stiffness, extensively evaluated primarily in the Japanese population. In this work, we performed a model-based analysis of the association between different population characteristics and CAVI or CAVI0 values in healthy Russian subjects and propose a tool for calculating the range of reference values for both types of indices.

Methods: The analysis was based on the data from 742 healthy volunteers (mean age 30.

Materials in the NaO-CaO-SiO-PO System for Medical Applications.

Calcium phosphate materials and materials based on silicon dioxide have been actively studied for more than 50 years due to their high biocompatibility and bioactivity. Hydroxyapatite and tricalcium phosphate are the most known among calcium phosphate materials, and Bioglass 45S5 is the most known material in the NaO-CaO-SiO-PO system. Each of these materials has its application limits; however, some of them can be eliminated by obtaining composites based on calcium phosphate and bioglass.

Formation of Hydroxyapatite-Based Hybrid Materials in the Presence of Platelet-Poor Plasma Additive.

Biomaterials based on hydroxyapatite with controllable composition and properties are promising in the field of regenerative bone replacement. One approach to regulate the phase composition of the materials is the introduction of biopolymer-based additives into the synthesis process. The purpose of present study was to investigate the formation of hydroxyapatite-based hybrid materials in the presence of 6-24% platelet-poor plasma (PPP) additive, at a [Ca]/[PO] ratio of 1.

Calcium Phosphate Cements as Carriers of Functional Substances for the Treatment of Bone Tissue.

Interest in calcium phosphate cements as materials for the restoration and treatment of bone tissue defects is still high. Despite commercialization and use in the clinic, the calcium phosphate cements have great potential for development. Existing approaches to the production of calcium phosphate cements as drugs are analyzed.

Electrospun Nanomaterials Based on Cellulose and Its Derivatives for Cell Cultures: Recent Developments and Challenges.

The development of electrospun nanofibers based on cellulose and its derivatives is an inalienable task of modern materials science branches related to biomedical engineering. The considerable compatibility with multiple cell lines and capability to form unaligned nanofibrous frameworks help reproduce the properties of natural extracellular matrix and ensure scaffold applications as cell carriers promoting substantial cell adhesion, growth, and proliferation. In this paper, we are focusing on the structural features of cellulose itself and electrospun cellulosic fibers, including fiber diameter, spacing, and alignment responsible for facilitated cell capture.

Bioceramics Based on β-Calcium Pyrophosphate.

Ceramic samples based on β-calcium pyrophosphate β-CaPO were prepared from powders of γ-calcium pyrophosphate γ-CaPO with preset molar ratios Ca/P = 1, 0.975 and 0.95 using firing at 900, 1000, and 1100 °C.

Fibrous Polymer-Based Composites Obtained by Electrospinning for Bone Tissue Engineering.

Currently, the significantly developing fields of tissue engineering related to the fabrication of polymer-based materials that possess microenvironments suitable to provide cell attachment and promote cell differentiation and proliferation involve various materials and approaches. Biomimicking approach in tissue engineering is aimed at the development of a highly biocompatible and bioactive material that would most accurately imitate the structural features of the native extracellular matrix consisting of specially arranged fibrous constructions. For this reason, the present research is devoted to the discussion of promising fibrous materials for bone tissue regeneration obtained by electrospinning techniques.

Resorbable Mg-Containing Phosphates for Bone Tissue Repair.

Materials based on Mg-containing phosphates are gaining great relevance in the field of bone tissue repair via regenerative medicine methods. Magnesium ions, together with condensed phosphate ions, play substantial roles in the process of bone remodeling, affecting the early stage of bone regeneration through active participation in the process of osteosynthesis. In this paper we provide a comprehensive overview of the usage of biomaterials based on magnesium phosphate and magnesium calcium phosphate in bone reconstruction.

Transforming Growth Factor-β1, Arterial Stiffness and Vascular Age in Patients With Uncontrolled Arterial Hypertension.

Background: Lack of blood pressure control leads to a higher incidence of hypertension-mediated target organ damage (HMOD). One of the markers of HMOD is an increased arterial stiffness, an independent predictor of cardiovascular complications. However, abstract numbers showing the level of arterial stiffness do not give patients a clear understanding of the risk of their condition.

TRANSFORMING GROWTH FACTOR AND ARTERIAL STIFFNESS IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION.

The aim of our study was to identify the relationship between TGF-β1, arterial stiffness, and target organ damage in patients with uncontrolled arterial hypertension (UAH). The study included 140 patients with hypertension: 30 people with uncontrolled hypertension (UAH), 80 people with controlled hypertension (CAH) and 30 people in the control group. All patients underwent determination of arterial stiffness using cardio-ankle vascular index (CAVI) and TGF-β1 level.

[Endothelial dysfunction in patients with controlled and uncontrolled arterial hypertension].

Aim: To conduct a comparative analysis of the level of asymmetric dimethylarginine (ADMA) in two groups of patients with a diagnosis of essential arterial hypertension (AH). Group I - patients with uncontrolled hypertension (UCAH) and group II - patients with controlled course of hypertension (CAH).

Materials And Methods: The study included 109 patients: group I - 73 patients with UCAH, group II - 36 patients with CAH.

VASCULAR AGE AND CARDIO-ANKLE VASCULAR INDEX IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSON.

Age is used in various algorithms to estimate cardiovascular risk. It is known that at the same age the health status of different patients can differ dramatically. The term vascular age (VA) was introduced in order to assess the severity of pathological process in the arterial wall.

Biocompatibility of biphasic α,β-tricalcium phosphate ceramics .

The biocompatibility of biphasic α,β-tricalcium phosphate ceramics, obtained by annealing a compact preform based on β-tricalcium phosphate powder, was studied . It was found that within 10-30 days the adhesion of primary dental pulp stem cells located on the surface of biphasic α,β-tricalcium phosphate ceramics is suppressed. Decrease of the cell number on the surface of biphasic α,β-tricalcium phosphate ceramics, most likely, can be associated with both the pH level (acidic) as a result of hydrolysis of the more soluble phase of α-tricalcium phosphate and with the nature of surface that changes as a result of the formation and growth of hydroxyapatite crystals.

Colloidal forming of macroporous calcium pyrophosphate bioceramics in 3D-printed molds.

A technique for colloidal forming of CaPO macroporous bioceramics, based on low-pressure injection molding (LPIM) of a glycerol-water slip containing CaPO and Ca(НPO) into a plastic mold fabricated via FDM 3D-printing, was proposed. Chemical reaction between the solid phases of the water containing slip - CaPO and Ca(НPO), resulting in brushite (CaHPO·2HO) formation, led to consolidation of the casting and preserved its complex architecture in the course of mold burning-out. Macroporous ceramics of Kelvin structure (70% macropores with the sizes from 2 up to 4 mm), based on a pre-defined composition with 10 wt% Ca(PO) and sintered in liquid-phase regime, demonstrated a compressive strength of 1.

Mantle Cell Lymphoma Case Report.

Introduction: Due to the beginning of the use of immunophenotypic and cytogenetic techniques, new nosological forms of lymphoproliferative diseases have appeared over the past few decades. According to the WHO classification (2008), today there are more than 50 known lymphoproliferative diseases.

Case Presentation: We present the case of a 51-year-old man with lymphoproliferative syndrome.

[The Input of Professor V. I. Kalmykova into Studying Pathogenesis of Atherosclerosis (to Ninetieth Anniversary)].

The atherosclerosis is considered among the most prevalent diseases. In Russia, N. N.

[The role of lipid metabolism and antioxidant system changes in the development of retinal vein occlusion].

Purpose: To compare changes in lipid metabolism and antioxidant status in patients with retinal vein occlusion (RVO) with that in patients with a history of ischemic stroke and in patients with no clinical manifestations of atherosclerosis.

Material And Methods: A total of 111 patients were enrolled in the study. Group 1 included 80 patients with RVO and grade 2-3 stage II-III essential hypertension, group 2-11 patients with grade 3 stage III essential hypertension, high cardiovascular risk and a history of ischemic stroke.

[[Dynamics of the dominance of identified cardioregulatory neurons in the snail Achatina fulica] ].

9 cardioregulating neurones belonging to 5 different functional groups were studied in visceral and right parietal ganglia of the Giant African snail Achatina fulica. The neuronal network included multimodal and multifunctional cells exerting short- or long-lasting chronoionotropic effects on the cardiac electro- and mechanograms. Mechanisms of the differences in the cardioregulating effectiveness of these groups were discussed.

[Modification of biochemical changes in developing cultures of chick embryo nerve tissue cultures].

The effects of exogenous ganglioside GM1 (1 microM) from bovine brain on the morphological state and biochemical parameters (creatine kinase, acetylcholinesterase and adenylate cyclase activities as well as the protein, phospholipid and ganglioside content) have been studied in primary cultures of trypsin-treated dissociated cells of chicken embryonic brain. Ganglioside GM1 accelerated the growth and differentiation of cultured cells, increased the phospho- and glycolipid content and stimulated the activity of the enzymes.

[The stimulation of the creatine kinase activity of tissue cultures with high-energy laser radiation].

Effects of copper laser stimulating doses on biochemical parameters of competent chicken embryo myoblast and neuroblast cultures were studied. It was shown that in both systems biostimulation was characterized by an increase of water-extractable protein level and a considerable rise of total and specific creatine kinase activity. The authors believe that cases of protein drop during myoblast culture exposure to chemical agents described in literature were caused by these agents overdosage and that this drop may be considered as a manifestation of a peculiar biochemical shock induced by overdosage.

[The mechanographic and biochemical characteristics of induced contractile activity in the frog bladder].

Contractile activity of the frog bladder induced by electrical stimulation of the IX spinal nerve was shown to have a tubocurarine-resistant component. Two main components of the induced motor response were revealed differing from each other in latency, duration and sensitivity to tubocurarine. One of the components seems to be maintained by the activity of cholinergic fibres of the pelvic nerve and ganglion apparatus of the bladder plexus whereas the other component seems to be due to the results of efferent action of sensory terminals on the smooth muscle cells.

[Fluorescent antibodies to creatine kinase for detecting the enzyme in tissue culture].

Different methods for the preparation of antibodies to rabbit FITC-labeled MM creatine kinase are compared. Highly specific fluorescent antibodies have been employed to detect MM creatine kinase in isolated cells and in tissue culture. Prospects for research and clinical diagnostic application of the direct method for the detection of creatine kinase in biological samples are discussed.

[Antigenic properties of BB creatine kinases from various tissues in hens].

Studies have been made on interaction between rabbit antiserum to BB creatine kinase from hen gizzard and BB creatine kinases from the brain, heart and gizzard of hen. The degree of interaction was evaluated by the intensity of fluorescence of the immune complexes labeled by a fluorescent dye. It was shown that the intensity of fluorescence of the immune complexes formed by BB creatine kinases from the brain and gizzard of hen is approximately the same, whereas that formed by BB creatine kinase from the heart is twice lower.