Safety of Different Weight-Based Dosing Strategies of Intravenous Acyclovir in Obese Patients: A Retrospective Cohort Study.

Background: In obese patients receiving intravenous (IV) acyclovir, conflicting data exist regarding the risk of acute kidney injury (AKI) with different weight-based dosing strategies: total body weight (TBW), adjusted body weight (AdjBW), and ideal body weight (IBW).

Objective: We aimed to compare the safety of the 3 dosing strategies in obese patients.

Methods: A retrospective cohort study including obese patients who received IV acyclovir during their inpatient admissions.