Publications by authors named "Safak C Uslu"
Although chimeric antigen receptor (CAR) T cell therapies have demonstrated promising clinical outcomes, durable remissions remain limited. To extend the efficacy of CAR T cells, we develop a CAR enhancer (CAR-E), comprising a CAR T cell antigen fused to an immunomodulatory molecule. Here we demonstrate this strategy using B cell maturation antigen (BCMA) CAR T cells for the treatment of multiple myeloma, with a CAR-E consisting of the BCMA fused to a low-affinity interleukin 2 (IL-2).
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- T cells are essential for fighting tumors and clearing infected cells by recognizing specific targets through T-cell receptors (TCRs) that bind to pMHC molecules on these cells.
- Current methods for creating pMHC molecules may miss important TCRs that target weaker, yet effective peptides, making personalized immunotherapy challenging.
- A new method using sortase and click chemistry enables the stable generation of pMHC molecules, improving their binding to TCRs and offering a more effective approach to study and target antigen-specific T cells for cancer treatment.