J Soc Gynecol Investig
September 2005
Objective: Pathologic placentation has been implicated in the pathogenesis of preeclamsia. We sought to assess the effect serum obtained from women with preeclampsia would have on JAR human choriocarcinoma cells regarding growth, invasiveness, and matrix metalloproteinase (MMP) secretion as compared to normotensive pregnant woman.
Methods: Blood was collected from 11 healthy pregnant women and from10 patients with preeclampsia at 28-33 weeks of gestation.