Publications by authors named "Saeko Tahara"
The cluster of differentiation 155 (CD155) is highly expressed on tumor cells and augments or inhibits the cytotoxic activities of natural killer (NK) cells and T cells through its receptor ligands DNAX accessory molecule 1 (DNAM-1) and T-cell immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT), respectively. Although CD155 is heavily glycosylated, the role of glycosylation of CD155 in the cytotoxic activity of effector lymphocytes remains unknown. Here, we show that the N-linked glycosylation at residue 105 (N105 glycosylation) in the first Ig-like domain of CD155 is involved in the binding of CD155 to both DNAM-1 and TIGIT.
View Article and Find Full Text PDFImmunological memory is a hallmark of the adaptive immune system. Although natural killer (NK) cells are innate immune cells important for the immediate host defence, they can differentiate into memory NK cells. The molecular mechanisms controlling this differentiation are yet to be fully elucidated.
View Article and Find Full Text PDFArticle Synopsis
- Transcription factors (TFs) show varying DNA-binding specificities in different cells and organisms, and traditional methods often yield multiple DNA motifs from single ChIP-seq samples, leaving much unexplored regarding TF diversity.
- The study utilized the MOCCS2 motif discovery method on a vast collection of human TF ChIP-seq data, compiling specificity score profiles for nearly 3,000 samples across various TFs and cell types, revealing that many TFs have distinct DNA-binding specificities based on the cell type.
- The research introduced a technique to identify differentially bound k-mers and suggested that variations in binding scores can help predict how genetic variants affect TF binding, offering insights into disease-related SNPs linked to TF activity
Article Synopsis
- - The study investigates how portal mesenchymal cells help develop bile ducts in the liver through the signaling component JAGGED1, which is linked to the genetic disorder Alagille syndrome.
- - Researchers identified three key transcription factors (SLUG, SOX2, and EGR1) that might regulate JAGGED1 expression, with a focus on SLUG as the most significant due to its strong presence in specific mesenchymal cells.
- - The findings enhance our understanding of the developmental biology involved in liver function and may offer insights into conditions like jaundice related to bile duct formation.