Assessment of atherosclerotic risk among patients with epilepsy on valproic acid, lamotrigine, and carbamazepine treatment.

Objective: To compare the long-term effects of carbamazepine (CBZ), valproic acid (VPA), and lamotrigine (LTG) as monotherapy on the markers of vascular risk.

Methods: The present cross-sectional study was carried out at the Department of Neurology, Jinnah Postgraduate Medical Centre (JPMC), Karachi, Pakistan, from 2012 to 2013. We selected 120 adult patients with epilepsy and 40 control subjects.

New single use supraglottic airway device with non-inflatable cuff and gastric tube channel.

Objective: To assess ventilatory characteristics and airway complications associated with the use of I-gel in patients undergoing gynaecological surgeries.

Study Design: Experimental study.

Place And Duration Of Study: Department of Anaesthesiology, Surgical Intensive Care Unit and Pain Management, Civil Hospital, Dow University of Health Sciences, Karachi, from July 2008 to June 2009.

Recovery profile - a comparison of isoflurane and propofol anesthesia for laparoscopic cholecystectomy.

Objective: To compare the recovery profile in terms of time of extubation, eye opening, orientation and mobility and frequency of Postoperative Nausea and Vomiting (PONV) between propofol and isoflurane based anesthesia in patients undergoing laparoscopic cholecystectomy with prophylactic antiemetic.

Study Design: Quasi-experimental study.

Place And Duration Of Study: Department of Anesthesia, Civil Hospital and Dow University of Health Sciences, Karachi, from January to April 2007.

Dexamethasone plus ondansetron for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a comparison with dexamethasone alone.

Objective: To compare the efficacy of combination of dexamethasone plus ondansetron with dexamethasone alone for postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

Study Design: Double blinded randomized controlled clinical trial.

Place And Duration Of Study: Department of Anaesthesiology, Surgical Intensive Care Unit and Pain Management, Dow University of Health Sciences and Civil Hospital, Karachi, from March 2007 to September 2007.

Single dose caudal tramadol with bupivacaine and bupivacaine alone in pediartic inguinoscrotal surgeries.

Objective: To determine the postoperative analgesic effect of Tramadol when given with caudally administered Bupivacaine in children undergoing inguinoscrotal surgeries.

Study Design: Quasi-experimental study.

Place And Duration Of Study: Department of Anaesthesia, Dow University of Health Sciences and Civil Hospital Karachi, from July 2005 to March 2006.

Use of recombinant activated factor VII for massive postpartum hemorrhage.

Objective: We hypothesised that patients with massive postpartum hemorrhage (PPH), defined as blood loss >1,500 ml,may benefit from the use of activated recombinant factor VII (rFVIIa). Design. Retrospective cohort study.

Intravenous ketamine attenuates injection pain and arterial pressure changes during the induction of anesthesia with propofol: a comparison with lidocaine.

Objective: To compare the effects of lidocaine and ketamine pretreatment on injection pain and hypotension due to propofol induction.

Design: Double blinded randomized controlled clinical trial. Place and Duration of the Study: Department of Anesthesiology, Surgical Intensive Care Unit and Pain Management, Dow University of Health Sciences and Civil Hospital, Karachi from February 2005 to December 2005.

Injection dexamethasone in preventing postoperative nausea and vomiting: a comparison with placebo in the patients undergoing laparoscopic cholecystectomy.

Objective: To determine the efficacy of intravenous dexamethasone for preventing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy (lap-chole) and comparing it with normal saline (placebo).

Study Design: Single blinded, randomized, placebo controlled, interventional study.

Place And Duration Of Study: This study was conducted in the department of Anaesthesiology of Civil Hospital, Karachi and Dow University of Health Sciences, Karachi, from June 2005 to April 2006.

Intrathecal fentanyl as adjunct to hyperbaric bupivacaine in spinal anesthesia for caesarean section.

Objective: To compare the effect of adding fentanyl to intrathecal bupivacaine on the onset, duration and quality of spinal anesthesia and its effect of mother and neonate.

Design: Single blind randomized controlled clinical trial.

Place And Duration Of Study: Department of Anesthesiology, Surgical Intensive Care Unit and Pain Management, Dow University of Health Sciences and Civil Hospital, Karachi, from January 2003 to June 2004.

Use of recombinant factor VIIa for massive postpartum haemhorrage: case series and review of literature.

Recombinant activated factor VII is indicated mainly for the treatment of patients with haemophilia inhibitors. It has also been found successful in the treatment of platelet disorder Glanzmann's thrombasthenia. Recently, its use in trauma patients and in patients with intracereberal haemorrhage has become well established.

Comparison of 25-gauge, Quincke and Whitacre needles for postdural puncture headache in obstetric patients.

Objective: To compare the frequency of postdural puncture headache (PDPH) and failure rate of spinal anesthesia using 25-gauge Quincke and 25-gauge Whitacre needles in obstetric patients.

Design: Single blinded, interventional experimental study.

Place And Duration Of Study: This study was conducted at the Department of Anesthesiology, Pain Management and Surgical Intensive Care Unit, Dow University of Health Sciences and Civil Hospital, Karachi from November 1, 2003-April 15, 2004.

Comparison of caudal bupivacaine and bupivacaine-midazolam for peri and postoperative analgesia in children.

Objective: To compare the duration and side effects of postoperative analgesia of caudal bupivacaine and bupivacaine-midazolam mixture.

Design: Single blinded, interventional experimental study.

Place And Duration Of Study: The Department of Anesthesiology and Surgical Intensive Care Unit, Dow Medical College and Civil Hospital, Karachi from May to November, 2002.