Publications by authors named "Saeed Sadeghian"
Article Synopsis
- The study investigated ECG abnormalities related to cardiac channelopathies linked to sudden cardiac death among adults in Tehran, Iran, highlighting their under-recognition in the region.
- Out of 7,350 analyzed ECGs, long QT intervals were the most common abnormality found at 3.08%, with several factors influencing their prevalence, such as age and lifestyle choices.
- Overall, those with abnormal ECG patterns had a significantly higher all-cause mortality rate (6.3%) compared to those without such patterns (2.96%), indicating potential health risks.
Article Synopsis
- New-onset postoperative atrial fibrillation (POAF) is common after coronary artery bypass grafting (CABG) and can increase stroke risk; this study compares the safety and feasibility of two anticoagulants, Warfarin and Rivaroxaban, in such patients.
- A randomized trial with 66 patients showed no thrombotic or major bleeding events in either group, although minor bleeding occurred with no significant difference.
- The findings suggest that both anticoagulants are safe and effective, potentially favoring Rivaroxaban for its convenience in managing POAF after CABG surgery.*
Article Synopsis
- * The study found that higher rates of insufficient PA were particularly evident among females, older adults, the unemployed, housewives, and those with lower education levels, with additional correlations to higher body mass index and certain health conditions.
- * Logistic regression analysis showed that factors like older age, unemployment, and chronic conditions were significantly linked to a lack of sufficient PA, highlighting a need for targeted interventions in specific demographics.
Purpose: Obesity is a chronic low-grade inflammatory condition with increasing global prevalence and is associated with cardiovascular diseases. In this study, we aimed to investigate the prevalence of obesity in the Tehran cohort study (TeCS) population.
Methods: We used the data collected by systematic random sampling during the recruitment phase of TeCS.
Background: Cardiovascular disease (CVD) is a major global health concern, the leading cause of death and disability. Thus, preventive interventions targeting modifiable risk factors are essential. Mobile-health technologies have emerged as promising tools for improving prevention by modifying risk factors.
View Article and Find Full Text PDFBackground: Cardiovascular diseases (CVDs) pose a significant global health concern and are the most common cause of death and disability, necessitating preventive interventions targeting modifiable risk factors. Recently, mobile-health technology has been developed to improve the delivery of cardiovascular prevention by risk factor modification. The "Green Heart" mobile application (app) was designed to aid in risk factor control among coronary artery disease (CAD) patients.
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- Dyslipidemia is a major risk factor for cardiovascular diseases (CVDs) and is increasingly prevalent, particularly in developing nations; a study in Tehran assessed its prevalence and lipid profile abnormalities among adults aged 35 and older.
- Analysis of data from over 8,000 participants revealed an 82.7% prevalence rate of dyslipidemia, with specific issues like hypertriglyceridemia and low HDL-C also reported at significant rates and varying by geographic areas within Tehran.
- The findings underscore the urgent need for public health initiatives focused on preventing and managing dyslipidemia to mitigate health risks in the Tehran population.
Objectives: Using the cardiac surgery database is of high importance in referral centers and can lead to a better quality of care for patients. Tehran Heart Center (THC) is a cardiovascular referral center that was inaugurated in 2001. In this report, we aimed to present the third report of trends in patients' cardiovascular risk factors and surgical procedures from 2002 to 2021 that have been gathered for all THC patients.
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- - High-density lipoprotein cholesterol (HDL-C) is considered important for heart health, particularly regarding coronary artery diseases, but research on its influence on outcomes after coronary artery bypass graft (CABG) surgery is limited.
- - A study of 17,772 CABG patients from 2007 to 2017 found that low HDL-C levels did not correlate with increased mortality or major adverse cardiovascular events one year post-surgery after adjusting for confounding factors.
- - The analysis revealed that, while no significant overall association between HDL-C levels and outcomes was identified, a sex-based evaluation showed that higher HDL-C levels may offer more protective benefits for males after CABG.
The burden of cardiovascular disease (CVD) is diminishing in developed countries. However, in middle- and low-income countries the CVD death rates are growing. CVD is the most common cause of death and disability in Iran and accounts for nearly half of all mortalities in Iranians.
View Article and Find Full Text PDFDetermining the recurrence rate of premature ventricular complexes and idiopathic ventricular tachycardia after radiofrequency catheter ablation with the help of designing a machine-learning model.
Regen Ther
December 2024
Ventricular arrhythmias increase cardiovascular morbidity and mortality. Recurrent PVCs and IVT are generally considered benign in the absence of structural heart abnormalities. Artificial intelligence is a rapidly growing field.
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- The study assessed the prevalence of substance and opium use among adult residents in Tehran, finding a 5.6% overall prevalence, with 95.8% of users favoring opium.
- It involved 8,259 participants and discovered that substance use was significantly more common in males (10.5% vs. 0.5% in females).
- The research identified male gender, alcohol intake, and smoking as key risk factors for opium use, suggesting that healthcare providers can use this data for preventive strategies.
Coronary artery disease (CAD), the most prevalent cardiovascular disease, is the leading cause of death worldwide. Heritable factors play a significant role in the pathogenesis of CAD. It has been proposed that approximately one-third of patients with CAD have a positive family history, and individuals with such history are at ~1.
View Article and Find Full Text PDFWe present a patient with a history of heart failure and metallic aortic and mitral valves surgeries, who required ablation for a drug-refractory left ventricular tachycardia. But the metallic valves prohibited the insertion of catheters via retrograde or via trans-septal approaches. Therefore, we decided to perform catheter ablation by direct left ventricle puncture through a minithoracotomy.
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- The study investigates the unnecessary use of brain MRI and EEG in diagnosing vasovagal syncope (VVS), as current guidelines do not recommend these tests for such cases.
- Out of 1882 patients analyzed, a significant number underwent MRI (43.04%) and EEG (52.34%), with certain factors like head trauma and previous neurologist visits positively influencing the likelihood of these tests being administered.
- The findings suggest that while many VVS patients were tested with MRI/EEG, such procedures are often not warranted, indicating a need to avoid inappropriate testing based on typical VVS history.
Article Synopsis
- The study examines the rising prevalence of acute coronary syndrome (ACS) in young adults, focusing on their risk factors and outcomes compared to older patients who underwent percutaneous coronary intervention (PCI).
- Researchers found that younger patients (mean age 48.39) had different risk factors, such as higher rates of family history, dyslipidemia, smoking, and opium addiction, compared to older patients (mean age 67).
- Despite differing risk profiles, younger ACS patients experienced higher in-hospital mortality rates, and no significant differences in long-term outcomes were observed, highlighting the need for careful secondary prevention strategies for younger individuals.
Background: There are still many uncertainties in the association between lipid profile and postcoronary artery bypass grafting (CABG) outcomes. Although simplifying the association to linear equations makes it understandable but cannot explain many findings.
Hypothesis: There is a nonlinear associatin between lipid profile indices and adverse outcomes after CABG.
Background: Octogenarians (age≥80 years) with coronary artery disease constitute a high-risk group and the elderly undergoing percutaneous coronary intervention (PCI) are at higher risk of adverse outcomes compared to young patients. In this study, we aimed to describe the outcomes of the elderly with acute coronary syndrome (ACS) who underwent PCI and also to identify the predictors of short-term major adverse cerebrocardiovascular events (MACCE) in octogenarians.
Methods: In this registry-based cohort study, we reviewed the data of patients (aged≥65 years) who underwent PCI.
Background: Although low-density lipoprotein-cholesterol (LDL-C) level is considered one of the main prognostic factors in patients with coronary artery bypass grafting (CABG), the question about "the lower the better" is still unanswered. We aimed to evaluate and compare the outcomes of patients with CABG and low or very low baseline LDL-C, regardless of statin usage.
Methods: In this registry-based cohort study, 10,218 patients with low/very low (70-100 and ≤ 70 mg/dL) baseline LDL-C who underwent isolated and the first-time CABG without known previous history of cardio-cerebrovascular events, were included and compared.
Background And Aims: Implantable cardioverter-defibrillators (ICDs) are frequently used to prevent sudden cardiac death in patients with high-risk arrhythmias. However, the use of ICD therapy in elderly patients beyond the predicted age of life expectancy is still controversial. We aimed to evaluate the predictors of mortality and clinical outcomes following ICD implantation in elderly patients.
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- A study analyzed ECG data from 7630 adults aged 35 and older to investigate age and gender differences in ECG parameters and abnormalities, finding notable variations between groups.
- Results showed that women had a higher average heart rate, while men exhibited longer QRS duration and RR intervals, with major ECG abnormalities slightly more prevalent in men, but differences weren't statistically significant.
- The study concluded that both major and minor ECG abnormalities were more common in men, and the likelihood of major ECG abnormalities increased significantly with age, particularly in participants over 65.
Background: Revascularization in diabetic patients with coronary artery disease remains a challenge in cardiology practice. Although clinical trials have reported the mid-term superiority of coronary artery bypass grafting (CABG) surgery over percutaneous coronary intervention in these patients, little is known about the long-term outcomes of CABG in diabetic patients compared to non-diabetics, particularly in developing countries.
Methods: Between 2007 and 2016, we recruited all patients who underwent isolated CABG in a tertiary care cardiovascular center in a developing country.
Article Synopsis
- Tobacco use is a significant health issue globally, particularly in low/middle-income countries, and a study was conducted in Tehran, Iran to evaluate the prevalence of different forms of tobacco use among 8,272 participants.
- The findings revealed that 19.8% were current tobacco users, with higher rates among younger individuals and men, and identified that education level, body mass index, physical activity, and use of opium and alcohol were associated with higher tobacco use.
- The study highlights the need for targeted interventions in Tehran to address the high prevalence of tobacco use, noting specific risk factors and the differing patterns of use between genders.
The spreading of opium use poses new health related concerns. In some areas of Asia its use is believed to protect from cardiovascular disorders, such as coronary artery disease (CAD). However, whether opium use has an association with CAD is unclear.
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- The INSPIRATION-S trial investigated the effects of atorvastatin versus placebo on 90-day outcomes in ICU patients with COVID-19, focusing on complications like thrombosis and mortality.
- Results showed that atorvastatin users had a slightly lower incidence of severe outcomes compared to placebo (33.1% vs 38.0%), but the difference was not statistically significant.
- The study indicated a potential benefit of atorvastatin, particularly for patients who began treatment within the first week of symptom onset, with improved functional status noted, although definitive conclusions couldn't be made.