Efficacy and tolerability of antipsychotic polypharmacy for schizophrenia spectrum disorders. A systematic review and meta-analysis of individual patient data.

Background: Antipsychotic polypharmacy (APP) is frequently prescribed for schizophrenia-spectrum disorders. Despite the inconsistent findings on efficacy, APP may be beneficial for subgroups of psychotic patients. This meta-analysis of individual patient data investigated moderators of efficacy and tolerability of APP in adult patients with schizophrenia-spectrum disorders.

Practicing Psychoanalysis and Psychodynamic Psychotherapies in Developing Societies.

Vital to the contemporary exercise of psychiatry is the biopsychosocial approach, with psychotherapy as its well-defined, and requisite, constituent. The key objectives of psychoanalysis and other related therapies are the amelioration of symptoms and modification of character by probing the unconscious. But the practice of psychoanalysis and similar insight-oriented techniques is in developing nations is different from developed countries due to cultural and educational reasons, along with a shortage of required facilities.

Olanzapine versus haloperidol in the management of borderline personality disorder: a randomized double-blind trial.

Introduction: The newer atypical antipsychotics seem to be as effective as previous antipsychotics for impulsivity and aggressiveness of patients with borderline personality disorder (BPD). Objective of this assessment was to compare the effectiveness of olanzapine versus haloperidol in BPD.

Method: Twenty-eight female inpatients, meeting the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, criteria for BPD, were randomly entered in one of the 2 matching contemporaneous groups for an 8-week parallel double-blind study.

Olanzapine vs. lithium in management of acute mania.

Objective: Among the available mood stabilizers, it appears that lithium may share an important role for treatment of acute mania. In a study from Sep. 2007 to Apr.