Publications by authors named "Saeed Mohammad"

Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a rare disorder characterized by chronic cholestasis usually progressing to end-stage liver disease (ESLD) within the first two decades of life. PFIC-3 is caused by pathogenic genetic variants of the ATP-binding cassette 4 (ABCB4) gene with variable inheritance; the most common is autosomal recessive. We present two cases of PFIC-3 with genetic testing confirming a novel genetic variant in ABCB4 with homozygous genotype c.

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RfaH is a crucial protein involved in anti-termination of transcription, which is necessary for spreading virulence in certain types of bacteria, such as Klebsiella pneumoniae and Escherichia coli. RfaH works by interacting directly with RNA polymerase and ribosomes, which activates the production of certain components needed for the bacteria's survival. Targeting RfaH offers a novel approach to hindering bacterial transcription and virulence.

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Background: The burden of atrial fibrillation (AF) hospitalizations in young patients is not well characterized. We aimed to study the burden, comorbidities, outcomes, and resource utilization of AF hospitalizations in young patients.

Methods: We conducted a retrospective analysis of all primary AF hospitalizations in patients 18-45 years of age using the National Inpatient Sample data from January 1, 2008 to December 31, 2019.

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Background: Left ventricular assist device (LVAD) recipients have a higher incidence of ventricular tachycardia (VT). However, the role of VT ablation in this population is not well-established.

Objectives: This single-center retrospective cohort study sought to examine the impact of post-LVAD implant VT ablation on survival.

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Background: Despite the importance of racial and ethnic representation in clinical trials, limited data exist about the enrollment trends of these groups in atrial fibrillation (AF) trials over time.

Objective: The purpose of this study was to examine the characteristics of contemporary AF clinical trials and to evaluate their association with race and ethnicity over time.

Methods: We performed a systematic search of all completed AF trials registered in ClinicalTrials.

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Aim: The success of layered restorations necessitates the utilization of an improved restorative material compatible with composite restorations. Therefore, in this line of research, the strength of adhesion of conventional resin-based dental composite to different filling materials was tested.

Materials And Methods: Conventional composite resin was bonded to four restorative materials (Group I: conventional glass ionomer cement (GIC), Group II: resin-modified glass ionomer cement, Group III: flowable composite, and Group IV: Cention-N) received no surface treatment (Subgroup A: control), sandblasting using 50-µm aluminum oxide particles (Subgroup B), sandblasting and resin adhesive (Subgroup C), acid etch and resin adhesive (Subgroup D), or self-etch resin adhesive (Subgroup E).

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Article Synopsis
  • Early diagnosis and proper management of epilepsy are crucial, yet Egypt faces significant challenges in healthcare practices, leading to poor outcomes for patients.
  • A group of Egyptian experts used a modified Delphi method to develop a nationwide consensus on epilepsy diagnosis and treatment after reviewing recent literature and guidelines.
  • Out of 278 statements discussed, a strong agreement was reached on 256, aiming to enhance the quality of care and improve treatment outcomes for those living with epilepsy in Egypt.
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Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing globally in pediatric populations. Currently, MASLD management primarily relies on lifestyle interventions, which pose challenges in sustaining long-term weight loss. This study investigated the use of weight loss medications in MASLD care through an international survey of 166 pediatric gastroenterologists and hepatologists.

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Background: Industry sponsorship is an important source of funding for atrial fibrillation (AF) clinical trials, the implications of which have not been analyzed.

Objective: The purpose of this study was to determine the characteristics of contemporary AF clinical trials and to evaluate their association with funding source.

Methods: We systematically assessed all completed AF trials registered in the ClinicalTrials.

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Background: Adolescent solid organ transplant recipients (aSOTRs) who received three doses of the COVID-19 mRNA vaccine experience high seroconversion rates and antibody persistence for up to 3 months. Long-term antibody durability beyond this timeframe following three doses of the SARS-CoV-2 mRNA vaccine remains unknown. We describe antibody responses 6 months following the third vaccine dose (D3) of the BNT162b2 mRNA vaccination among aSOTRs.

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SARS-CoV-2 infection during the Omicron period was frequent amongst a cohort of vaccinated pediatric solid organ transplant recipients (pSOTRs) despite robust anti-receptor-binding domain (anti-RBD) antibody response, suggesting poor neutralizing capacity against Omicron subvariants. Breakthrough infections among pSOTRs were overall limited in severity.

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Article Synopsis
  • The research focuses on creating PVP and PVA nanofiber composite scaffolds enhanced with hydroxyapatite (HA) nanoparticles and alendronate (ALN) for bone and tissue regeneration using electrospinning techniques.
  • Analysis, including SEM and EDX, confirmed successful incorporation of HA and ALN, with nanofiber diameters around 200-250 nm, showcasing the materials' physicochemical stability and compatibility.
  • The findings highlight the non-toxic, biocompatible nature of the scaffolds and their potential to promote bone growth and inhibit harmful osteoclast activity, suggesting significant applications in bone regeneration therapy.
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Immunosuppression reduction after liver transplant is an important strategy to mitigate long-term medication side effects. We describe our center's experience with immunosuppression minimization to once-daily calcineurin inhibitor dosing. Success was defined as continuing daily calcineurin inhibitor monotherapy with normal transaminases and no rejection.

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Tissue engineering (TE) has become a primary research topic for the treatment of diseased or damaged tendon/ligament (T/L) tissue. T/L injuries pose a severe clinical burden worldwide, necessitating the development of effective strategies for T/L repair and tissue regeneration. TE has emerged as a promising strategy for restoring T/L function using decellularized extracellular matrix (dECM)-based scaffolds.

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Background: Postoperative atrial fibrillation (POAF) frequently complicates cardiac surgery. Predicting POAF can guide interventions to prevent its onset. This study assessed the incidence, risk factors, and related adverse outcomes of POAF after cardiac surgery.

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Background: Implantable cardioverter-defibrillator (ICD) therapy is recommended to reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF). Frailty is common among patients with HFrEF and is associated with increased mortality risk. Whether the therapeutic efficacy of ICD is consistent among frail and nonfrail patients with HFrEF remains unclear.

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Article Synopsis
  • Microplastics in Arctic waters are contaminated with harmful substances like heavy metals and PAHs, posing significant health risks to local communities that depend on local food sources.
  • The paper introduces a new ecotoxicity model designed to evaluate the health risks associated with microplastics, focusing on their potential to cause cancer through human ingestion.
  • The model combines factors such as environmental conditions and human biology to assess cancer risks and will help develop effective risk management strategies for Arctic Indigenous peoples.
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A recent increase in reports of severe acute hepatitis of unknown etiology in children is under investigation. Although adenovirus has been frequently detected, its role remains unclear, and systematic histopathologic analysis is lacking. We conducted a retrospective study of 11 children hospitalized between October 2021 and May 2022 with unexplained acute hepatitis and concurrent adenovirus infection.

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Article Synopsis
  • Implantable loop recorders (ILR) are used to detect atrial fibrillation (AF) in patients who have experienced cryptogenic strokes, but there's limited long-term data on their effectiveness and impact on stroke prevention.
  • A study conducted at Baylor College analyzed 225 patients with ILR to assess how many were diagnosed with AF and the rates of subsequent strokes, finding a 28.6% AF detection rate over 36 months and 13.8% had recurrent strokes.
  • The results showed a high false positive rate for AF diagnoses, with most patients who had recurrent strokes not diagnosed with AF during the monitoring period.
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Left atrial appendage occlusion (LAAO) is effective in preventing thromboembolism. Risk stratification tools could help identify patients at risk for early mortality after LAAO. In this study, we validated and recalibrated a clinical risk score (CRS) to predict risk of all-cause mortality after LAAO.

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Introduction: Living donor liver transplantation (LDLT) reduces liver transplant waitlist mortality and provides excellent long-term outcomes for persons with end stage liver disease. Yet, utilization of LDLT has been limited in the United States (US).

Methods: In October 2021, the American Society of Transplantation held a consensus conference to identify important barriers to broader expansion of LDLT in the US, including data gaps, and make recommendations for impactful and feasible mitigation strategies to overcome these barriers.

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