The history of medieval bladder stone surgery in Persia.

Introduction: People's understanding of bladder stones has a long history. Since around the sixth century BC, surgery has been selected as the most specialized and last treatment and has continuously evolved. Meanwhile, many missing links have sometimes been a turning point in bladder stone surgery.

Electrospun PCL/PVA/PHMB nanofibers incorporating fruit extract as promising wound dressings with potent antibacterial and antidiabetic properties.

This investigation examined the potential antibacterial and antidiabetic effects of wound dressings created using electrospun nanofibers containing fruit extract (ZJ). These nanofibers were composed of a combination of Polycaprolactone (PCL), Polyvinyl Alcohol (PVA), and Polyhexamethylene Biguanide (PHMB). The process of creating these nanofibers involved electrospinning.

An approach to the milestones of spine surgery in Persian traditional medicine.

Background: The diagnosis and treatment of spine disorders have been challenging for thousands of years in different nations and medical schools. Despite this long history, there are many information gaps in this regard. The current research deals with the milestones and progress of spine surgery from ancient times until now, emphasizing the innovations of sages in the Persian traditional medicine era.

Role of Farnesoid Receptors and Nrf2-mediated Genes in Gentamicin-induced Nephrotoxicity in Rat: A Time-course Study.

Introduction: Farnesoid-X-activated receptor (FXR) is considered as an upstream controller which could influence the other key regulatory genes encoding cellular antioxidant defense system.

Methods: Thirty-five male Wistar rats (240 ± 20 g) were randomly allocated into five groups: 1) control, 2) received gentamicin (100 mg/kg/d) for three days (GM-3d), 3) seven days (GM-7d), 4) 10 days (GM-10d), and 5) 14 consecutive days (GM-14d). Biochemical measurements of BUN and serum creatinine (SCr), histological assessment of renal samples as well as molecular analysis using real-time qRT-PCR were used to investigate the pattern of changes in different levels.

The historical course of varicose vein surgery in the Persian medicine.

Introduction: Dawali (varicose veins) is the disease of chronic dilation of veins. The veins of the legs become dilated and blue due to excessive accumulation of blood. This disease and the effort to identify and treat it has a very long history.

Cannabidiol interacts with the FXR/Nrf2 pathway and changes the CB1/CB2 receptors ratio in gentamicin-induced kidney injury in rats.

Objectives: Gentamicin-induced nephrotoxicity was used as an experimental model of kidney disease. The present study was performed to assess the therapeutic role of cannabidiol (CBD) against gentamicin-induced renal damage.

Materials And Methods: Forty two male Wistar rats were randomly allocated into 6 groups (n=7), including: (1) Control, (2) Vehicle, (3) Gentamicin-treated group (100 mg/kg/day) for 10 days (GM), (4-6) 3 Gentamicin-CBD-treated groups (2.

Cauterization's history in the Persian medicine school.

Background: Cauterization has been used in various medical schools to prevent and treat diseases. Its application dates back to shortly after the invention of fire. Despite its long history, different aspects and the importance of cauterization in various medical schools have remained elusive.

Comparison of the effects of alcoholic extract of aerial parts of and atorvastatin on the lipid profile and thyroid hormones in hypercholesterolemic rats.

Objective: Decreased thyroid hormones along with increased blood fats and overweight, lead to atherosclerosis and eventually cardiovascular disease. The aim of this study was to compare the effects of alcoholic extract of aerial parts of and atorvastatin on the lipid profile and thyroid hormones in hypercholesterolemic rats.

Materials And Methods: In this study, 40 male Wistar rats were divided into 5 groups (n=8): control, hypercholesterolemic vehicle and three experimental groups.

The physiological and pharmacological effects of L.: A review study.

Objective: Many reports have revealed preventive and therapeutic effects of ; however, few systematic reviews have evaluated such effects. The present study reviews the physiological and pharmacological effects of extract and its components.

Materials And Methods: English articles were searched in international databases, such as Embase, Scopus, and PubMed; Persian studies were also searched in national databases such as SID and Magiran.

Abu Al Qasim Al Zahrawi (Albucasis) and types of his used surgical knives.

Background: Surgical incisions require surgical knives. Different surgical knives have been used for surgical practice since its first appearance in surgical science, and evolved according to its progress. Albucasis, Spanish physician (936-1013 AD), is one of the surgical science pioneers whose initiatives in therapeutic and surgical methods are appreciable, as are his surgical instruments including numerous surgical knives.

The effect of adipose-derived mesenchymal stem cells on renal function and histopathology in a rat model of ischemia-reperfusion induced acute kidney injury.

Objectives: It has been shown that adipose-derived mesenchymal stem cells (AD-MSC) have protective effects in acute kidney injury (AKI). This study was conducted to assess the therapeutic effects of AD-MSC in rats subjected to acute kidney injury by 45 min of renal ischemia followed by 48 hr of reperfusion (I/R).

Materials And Methods: 28 male Wistar rats were divided into four groups, including control, 48-hr sham, 48-hr I/R, and 48-hr I/R receiving AD-MSC.

The effect of hydro-alcoholic extract of on spermatogenesis index in rats treated with cyclophosphamide: An experimental study.

Background: The aim of this study was to investigate the antioxidant effects of extract on improving the toxicity induced by cyclophosphamide (CP) on spermatogenesis. 54 male Wistar rats (4 months old) weighing 200-250 gr were randomly divided into 6 groups (n = 9/each).

Objective: "group 1 (control) underwent the normal diet and water; group 2 (sham) received 2 ml/day normal saline; group 3 (positive control) received 300 mg/kg/day extract; group 4 received extract (300 mg/kg/day) + 5 mg/kg/day CP (Endoxan, baxter oncology gmbh, Germany) after 4 hr; group 5 (CP) received 5 mg/kg/day CP + normal saline 4 hr after it; and group 6 (CP + ) received extract (300 mg/kg/day) 4 hr after 5 mg/kg/day CP.

Stem Cell Therapy Ameliorates Ischemia-reperfusion Induced Kidney Injury After 24 Hours Reperfusion.

Introduction: The mortality rate in patients with acute kidney injury (AKI) is high. The aim of this study was to evaluate the efficacy of treatment with adipose-derived mesenchymal stem cells (AD-MSC) in renal ischemia-reperfusion (I/R) model in rats.

Methods: In this study 28 male Wistar rats were divided into four groups of control, sham, I/R24h+PBS, and I/R24h+AD-MSC.

Protective Effects of Pomegranate Juice on Nephrotoxicity Induced by Captopril and Gentamicin in Rats.

Introduction: Nephrotoxicity is an important side effects of captopril and gentamicin. This study investigated the prophylactic and protective effects of pomegranate juice (PJ) on the kidney exposed to nephrotoxicity induced by these medications.

Materials And Methods: Wistar male rats received drinking water (groups 1 to 3) or PJ at doses of 4 mL/kg (group 4), 10 mL/kg (groups 5 and 7), and 15 mL/kg (group 6) for 14 days.

Protective effect of Malva sylvestris L. extract in ischemia-reperfusion induced acute kidney and remote liver injury.

Mallow (Malva sylvestris L.) has had medicinal and therapeutic uses in addition to its oral consumption. The present study was conducted to examine the protective effect of Malva sylvestris L.

Antioxidant activity of omega-3 derivatives and their delivery via nanocages and nanocones: DFT and experimental in vivo investigation.

The antioxidant properties of omega-3 were investigated via experimental in vivo and theoretical methods. For experimental evaluation, oxidative stress was induced by 30 min bilateral renal ischemia and 24 h of reperfusion in male Sprague Dawley rats. The oxidative stress was evaluated through measuring malondialdehyde (MDA) and ferric reducing/antioxidant power (FRAP) levels in renal tissue.

Pimpinella anisum L. ethanolic extract ameliorates the gentamicin- induced nephrotoxicity in rats.

Aim: Gentamicin (GM) is one of the commonest causes of drug-induced nephrotoxicity. Moreover, oxidative stress plays an important role in gentamicin-induced nephrotoxicity. The current study aimed to explore the antioxidant and protective effects of Pimpinella anisum (P.

Anti-inflammatory and protective effects of saffron extract in ischaemia/reperfusion-induced acute kidney injury.

Aim: Inflammation is one of the major challenges in the management of ischaemia/reperfusion (I/R)-induced acute kidney injury. Our aim was to assess the anti-inflammatory and protective effects of saffron extract against I/R-induced renal disturbances.

Methods: A total of 35 male Wistar rats were randomly divided into five groups (n = 7) as sham, I/R and three groups of I/R that were pretreated with different doses of saffron extract (5 mg/kg, 10 mg/kg, or 20 mg/kg) intraperitoneally.

Therapeutic effects of curcumin on the functional disturbances and oxidative stress induced by renal ischemia/reperfusion in rats.

Objective: Curcumin has anti-inflammatory and antioxidative properties. The objective of this study was to investigate the therapeutic effects of curcumin on functional disturbances, oxidative stress, and leukocyte infiltration induced by renal ischemia/reperfusion (I/R).

Materials And Methods: Animals were randomly divided into 9 groups.

A quick overview on some aspects of endocrinological and therapeutic effects of Berberis vulgaris L.

Many herbaceous plants contain compounds that have biological effects in addition to their medicinal properties. They have compounds with numerous properties, including hypo lipidemic, hypoglycemic, antioxidant, and hepato protective ones, which have been analyzed at different levels. One of these plants, with the scientific name of Berberis vulgaris, is barberry.

A study on the effects of the hydroalcholic extract of the aerial parts of Alhagi camelorum on prolactin and pituitary-gonadal activity in rats with hypercholesterolemia.

Background: Although endocrine disorders are not a common cause of infertility, in some cases, testing thyroid function, and hypothalamus - pituitary - gonadal axis can determine the cause of infertility. We aimed to investigate the effect of the aerial parts of Alhagi camelorum extract on prolactin, cortisol and pituitary - gonadal axis activities in rats with hypercholesterolemia.

Materials And Methods: In this study, 35 male wistar rats in 5 groups (n = 7) were assigned as: control group with normal diet, the sham group with fat diet and three experimental groups of hypercholesterolaemic animals which received Alhagi camelorum extract at a minimum dose of 100 mg/kg, average dose of 200 ml/kg and maximum dose of 300 mg/kg over a period of 21 days.