Comparative Assessment of the Influence of Various Time Intervals upon the Linear Accuracy of Regular, Scannable, and Transparent Vinyl Polysiloxane-Based Bite Registration Materials for Indirect Dental Restoration Fabrication.

Interocclusal records (IORs) created with bite registration materials (BRMs) accurately reflect the opposing teeth's physiological and anatomical associations in digital and traditional dentistry. This study assessed the linear dimensional accuracy of vinyl polysiloxane-based scannable and transparent BRMs over obligatory clinical time intervals (1, 24, 72, and 168 h/s). A total of 3 scannable [Flexitime Bite, Occlufast CAD, Virtual CADBite] and 3 transparent [Maxill Bite, Charmflex Bite, Defend ClearBite] VPS-based BRMs were divided into 28 subgroups by time interval: 1, 24, 72, and 168 h/s.

Dimensional Accuracy of Intraoral Scanners in Recording Digital Impressions of Post and Core Preparations: A Systematic Review.

Background: This study aims to perform a review by selecting, analyzing, and evaluating articles that discuss the accuracy of intraoral scanners (IOSs) in recording post space compared to conventional impression-making techniques.

Methods: The review question framed using the PITR framework (participant, index test, targeted condition, and reference standard) is as follows: What is the dimensional accuracy (T) of impressions made using intraoral scanners (I) for post space (P) compared to impressions made using conventional techniques and digitalized using extraoral scanners (R)? Four electronic databases were searched using pre-set keywords. The guidelines and strategies recommended by PRISMA formed the basis for planning, executing, and documenting this systematic review.

Evaluation of the relationship between infected gastric mucosa and prognosis of gastrointestinal stromal tumor.

Objective: Gastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumor accounting for 2.2% of all malignant gastric tumors. Mesenchymal stem cells (MSCs) play crucial roles in gastric carcinogenesis.

Coexistence of Hodgkin Lymphoma and Squamous Cell Carcinoma of the Tongue: A Case Report and Literature Review.

We report an unusual case of a 39-year-old male patient with a previous history of treated classical Hodgkin lymphoma, presenting with tongue ulcer and left ear pain who was subsequently diagnosed with invasive squamous cell carcinoma of the oropharynx. This case highlights the importance of vigilance in patients with a history of lymphoma and the potential for the development of secondary malignancies. We discuss the clinical, radiological, and pathological findings and emphasize the need for close monitoring and early intervention in such cases.

Accuracy of 3 Intraoral Scanners in Recording Impressions for Full Arch Dental Implant-Supported Prosthesis: An In Vitro Study.

BACKGROUND This study used an edentulous mandibular resin model with 6 parallel osteotomy sites and aimed to compare the accuracy (trueness and precision) of 10 digital impressions using 3 intraoral scanners, the 3Shape TRIOS 5, Medit i700, and Primescan, using Medit Link v3.3.2 software.

The Thematic Analysis of Barriers to Immediate Post-Partum Long-Acting Reversible Contraception.

Background: Globally, many women express the desire to avoid immediate pregnancy for 24 months postdelivery, and only forty percent use contraceptives during this period. There is an enormous demand for postpartum family planning, particularly in developing countries with low- or middle-income grades. Postpartum intrauterine devices such as long-acting reversible contraceptives (LARCs) are among the most effective methods of family planning in the immediate postpartum period, yet their effectiveness is hindered because of a lack of availability and training.

Digital impression (intraoral scanners) and factors affecting its accuracy - an insight into knowledge and awareness amongst graduates, and clinical practitioners.

Background: This study aimed to evaluate the knowledge, awareness, and practice of intraoral scanners (IOS) and the factors affecting their accuracy amongst dental interns and practitioners.

Methods: This was an observational cross-sectional study in which data was collected from a representative population in Saudi Arabia, with the help of online questionnaires. The forms were distributed to 500 dental interns and practitioners and the questionnaire's validity and reliability were evaluated for vetting and remarks.

Inflammation impacts androgen receptor signaling in basal prostate stem cells through interleukin 1 receptor antagonist.

Chronic prostate inflammation in patients with benign prostate hyperplasia (BPH) correlates with the severity of symptoms. How inflammation contributes to prostate enlargement and/or BPH symptoms and the underlying mechanisms remain unclear. In this study, we utilize a unique transgenic mouse model that mimics chronic non-bacterial prostatitis in men and investigate the impact of inflammation on androgen receptor (AR) in basal prostate stem cells (bPSC) and their differentiation in vivo.

Investigating colostomy-related morbidity in children following stoma formation and closure in a tertiary hospital, Abha, Saudi Arabia: a retrospective cohort study 2024.

Background: Overall, stoma-related morbidity affects a reported 20-38% of pediatric patients. However, determining the true incidence of major stoma-related morbidity is challenging due to limited cohort sizes in existing studies. Thus, the aim of this study was to investigate colostomy related morbidity among children both after stoma formation and stoma closure.

Comparison of Various Surface Treatment Procedures on the Roughness and Susceptibility to Staining of Provisional Prosthodontic Materials.

Esthetically pleasing temporary prostheses are often necessary for extended periods in a variety of clinical scenarios. Adjustments to the occlusion or margins are commonly needed before cementing the temporary prosthesis. Therefore, it is clinically necessary to repolish the rough surface to avoid biological and esthetic issues associated with rough surfaces.

Effects of Weather on the Severity of Menstrual Symptoms Among College- and High School-Going Women in the Southern Regions of Saudi Arabia.

Background: The effects of weather on the severity of menstrual symptoms have been a topic of interest and research for many years. While some studies have shown a correlation between weather conditions and increased severity of menstrual symptoms, others have found no significant relationship.

Objective: The current study aimed to assess the effects of weather on the severity of menstrual symptoms among women going to college and high school in the southern regions of Saudi Arabia.

Mucosal immunity in COVID-19: a comprehensive review.

Mucosal immunity plays a crucial role in defending against coronaviruses, particularly at respiratory sites, serving as the first line of defense against viral invasion and replication. Coronaviruses have developed various immune evasion strategies at the mucosal immune system, hindering the recognition of infected cells and evading antibody responses. Understanding the immune mechanisms and responses is crucial for developing effective vaccines and therapeutics against coronaviruses.

Evaluation of pharmacokinetic target attainment and hematological toxicity of linezolid in pediatric patients.

Background: Linezolid is commonly used to treat severe and/or resistant Gram-positive infections. Few studies have assessed its pharmacokinetic (PK) target attainment in pediatrics.

Objective: To evaluate the percentage of pediatrics achieving the PK targets of linezolid with standard dosing regimens and to assess the incidence and risk factors associated with its hematologic toxicity.

Knowledge, attitudes, and practices of adults in the Kingdom of Saudi Arabia regarding -induced gastric ulcers, cancers, and treatment.

(HP) infection presents a significant threat to global health with serious associated morbidities. This study aimed to assess awareness, attitudes, and practices related to HP in the Kingdom of Saudi Arabia (KSA) through a survey-based cross-sectional study involving 2,541 respondents. We used a structured online questionnaire to gather data on personal and sociodemographic characteristics, as well as HP-related knowledge, attitudes, and practices.

The Relationship Between Gestational Diabetes and Postpartum Depression: A Systematic Review.

This study aims to examine the relationship between gestational diabetes mellitus (GDM) and the likelihood of postpartum depression (PPD) symptoms. PubMed, Scopus, Web of Science, ScienceDirect, and the Wiley Online Library were systematically searched for relevant literature. Our results included eight studies with a total of 4,209 women diagnosed with GDM and/or PPD.

Brain Tumor MRI Classification Using a Novel Deep Residual and Regional CNN.

Brain tumor classification is essential for clinical diagnosis and treatment planning. Deep learning models have shown great promise in this task, but they are often challenged by the complex and diverse nature of brain tumors. To address this challenge, we propose a novel deep residual and region-based convolutional neural network (CNN) architecture, called Res-BRNet, for brain tumor classification using magnetic resonance imaging (MRI) scans.

Optimizing Prostate Imaging Practices in Saudi Arabian Hospitals: A Comprehensive Analysis of PI-RADS Compliance in Multiparametric MRI.

Background: Prostate cancer, a significant contributor to male cancer mortality globally, demands improved diagnostic strategies. In Saudi Arabia, where the incidence is expected to double, this study assessed the compliance of multiparametric MRI (mpMRI) practices with Prostate Imaging-Reporting and Data System version 2 (PI-RADS v2) guidelines across diverse healthcare institutions.

Methods: A survey was distributed to the radiology departments of all tertiary referral hospitals in Saudi Arabia (n=60) to assess their compliance with the technical specifications outlined in PI-RADS v2.

Impact of Obesity on Echinocandin Effectiveness in Treating Candida Infections: A Retrospective Observational Cohort Study.

Introduction: Echinocandins are used to treat invasive candidiasis (IC), with FDA-approved doses indicated for both obese and non-obese patients. Pharmacokinetic (PK) studies have identified subtherapeutic exposure in obese patients receiving standard doses (SDs) of echinocandins. However, research on clinical outcome differences of echinocandins' SDs between obese and non-obese patients is lacking.

Leveraging multivariate analysis and adjusted mutual information to improve stroke prediction and interpretability.

Objectives: To develop a machine learning model to accurately predict stroke risk based on demographic and clinical data. It also sought to identify the most significant stroke risk factors and determine the optimal machine learning algorithm for stroke prediction.

Methods: This cross-sectional study analyzed data on 438,693 adults from the 2021 Behavioral Risk Factor Surveillance System.

Quality of Life Outcomes Following Aortofemoral and Iliofemoral Bypass Surgery in Patients With Peripheral Arterial Disease: A Two-Year Follow-Up Study.

Introduction: Peripheral arterial disease is a circulatory disorder characterized by reduced blood flow to the extremities, predominantly affecting the lower limbs. This study aims to evaluate the impact of aortofemoral and iliofemoral bypass surgeries on patients' quality of life two years post operation and identify predictors of quality-of-life improvements.

Methods: This cross-sectional study included adult patients with aortoiliac disease who underwent bypass surgery (aortofemoral or iliofemoral) at East Jeddah General Hospital from January 2020 to December 2022.

Vagal Nerve Stimulation in the Pediatric Population and Correlation between Family and Treatment Team Perspectives: Single-Center Experience.

Background:  Vagal nerve stimulation (VNS) is an adjunctive therapy to pharmacologic treatment in patients with drug-resistant epilepsy. This study aimed to assess the efficacy of VNS therapy for seizure frequency reduction and improving the quality-of-life (QOL) measures in children with refractory epilepsy and to evaluate the correlation between the perspectives of families and those of the treating team.

Methods:  This was a prospective cohort study conducted at Abha Maternity and Children's Hospital, Saudi Arabia, from 2018 to 2022.

The Impact of Repeated Steam Sterilization Cycles on the Efficacy of Chairside Adjustment Kits for Polishing Monolithic Multi-Layered Zirconia Dental Restoration Material.

BACKGROUND Before insertion, chairside adjustment kits are heat sterilized for positioning and polishing dental restorations. This study aimed to evaluate the effects of 2 steam sterilization cycles on the efficacy of polishing highly translucent monolithic zirconia (HTMLZ) dental restoration material. MATERIAL AND METHODS 100 HTMLZ disc-shaped specimens were adjusted (grinding, finishing, polishing) with EVE Diacera kit.

Photoacoustic imaging in prostate cancer: A new paradigm for diagnosis and management.

The global health issue of prostate cancer (PCa) requires better diagnosis and treatment. Photoacoustic imaging (PAI) may change PCa management. This review examines PAI's principles, diagnostic role, and therapeutic guidance.