Publications by authors named "Sae-Hwan Kim"
Article Synopsis
- There is a significant issue in biobanking related to inconsistent procedures during sample collection, preparation, and storage, which leads to quality control challenges for stored blood samples.
- This study analyzed blood samples from a biobank, assessing the quality of extracted DNA and RNA and measuring serum protein levels to establish quality indicators.
- Results indicated that only half of older samples had intact DNA, while RNA integrity was largely lacking, highlighting the need for standardized quality assessment guidelines for biobanked blood samples.
Neuronal accumulation of 1-methyl-4-phenylpyridinium ion (MPP(+)), the metabolite of neural toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine (MPTP), induces a rapid depletion of cellular ATP level and loss of neuronal cell viability which simulates human Parkinson's disease (PD). Since ATP plays an important role in the physiology and function of platelets, which share many biochemical and physiological features with neuronal cells, we examined the effect of MPP(+) on platelet aggregation and viability using freshly isolated rat platelets. While the treatment of MPP(+) to platelets did not induce cytotoxicity, it significantly attenuated agonist-induced platelet aggregation in a concentration dependent manner.
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