Publications by authors named "Sae-Bom Park"
Biol Pharm Bull
July 2017
Article Synopsis
- The study developed a new method called cassette PAMPA to test the intestinal permeability of lipophilic compounds in drug discovery.
- This method utilized a double-sink setup with a pH gradient and a surfactant to improve the accuracy of permeability screening, especially for certain compounds.
- Results showed that initial tests had two false negatives, but adding polysorbate 80 improved recovery and permeability, allowing clear differentiation of compound classes and a strong correlation with existing permeability data.
