Publications by authors named "Sae Utsumi"
Background: Posterior reversible encephalopathy syndrome (PRES) is known as a transfusion-related complication with typically favorable prognosis and no report fatalities. Pathological evaluation of PRES is also scarce.
Case Report: An 88-year-old female with myelodysplastic syndromes (MDS) attended our hospital because of a compression fracture and chronic heart failure with chronic anemia.
Article Synopsis
- * Congenital thrombotic thrombocytopenic purpura (cTTP) was suspected, prompting tests for ADAMTS13 activity, which revealed severely decreased activity but no inhibitors present.
- * The combination of test results and genetic testing in her family confirmed a diagnosis of cTTP, highlighting the need for careful evaluation of ITP patients for potential cTTP during follow-up.
Article Synopsis
- * Initial tests for leukemia-related chimeric genes were negative, but karyotyping revealed an inversion in chromosome 16, which led to further analysis confirming the CBFB::MYH11 fusion gene through advanced techniques like FISH and RNA sequencing.
- * This case demonstrates a rare subtype of the CBFB::MYH11 fusion gene that can result in false-negative findings with standard screening, highlighting the importance of using modified PCR primers, FISH, and RNA sequencing for accurate diagnosis.
Hematologic diseases frequently affect people >60 years old, and allogeneic stem cell transplantation (allo-SCT) is a potentially curative treatment for these patients. Although several multicenter studies proposed the risk assessment of allo-SCT for the elderly, they receive different treatments and management at each facility. Therefore, accumulating data from institutions that exhibit relatively the same treatment policy and patient care is important.
View Article and Find Full Text PDFDonor-derived hematological malignancies have been recognized as rare but serious late complications in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Most cases in the literature were diagnosed as myelodysplastic syndrome or acute leukemia, with very few malignant lymphoma reported. We herein present another case of donor-derived Burkitt lymphoma that occurred 9 years after allo-HSCT under continued administration of immunosuppressants for chronic graft-versus-host disease (GVHD).
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