Too fast and too furious: thermoanalytical and quantum chemical study of the thermal stability of 4,4'-dinitro-3,3'-diazenofuroxan.

Novel energetic materials (EM) often combine two intrinsically counter trends, , a high energy density and mediocre safety parameters, like thermal stability and sensitivity toward mechanical stimuli. A rational design of promising EMs requires a proper understanding of their thermal stability at both macroscopic and molecular levels. In the present contribution, we studied in detail the thermal stability of 4,4'-dinitro-3,3'-diazenofuroxan (DDF), an ultrahigh-performance energetic material with a reliable experimental detonation velocity being very close to 10 km s.

Features of α-Adrenergic Regulation of Isolated Rat Heart after Hypokinesia.

We studied the effect of the α-adrenergic receptor agonist clonidine hydrochloride (10-10 M) on the isolated heart of adult rats after 30-day restriction of motor activity. In hypokinetic rats, in comparison with control animals, clonidine caused a positive inotropic effect; the dynamics of coronary flow was changed after stimulation of α-adrenergic receptors by clonidine in the minimum and maximum concentrations. Moreover, clonidine in concentrations of 10 and 10 M reduced coronary flow both in the control group and against the background of hypokinesia.

Isolation and Characterization of Bacteria with High Electroactive Potential from Poultry Wastewater.

Natural resources are in short supply, and the ecosystem is being damaged as a result of the overuse of fossil fuels. The creation of novel technology is greatly desired for investigating renewable and sustainable energy sources. Microorganisms have received a lot of interest recently for their potential to transform organic waste into sustainable energy and high-value goods.

Blood Markers of Biological Age Evaluates Clinic Complex Medical Spa Programs.

Background: Kivach Clinic has developed a special medical spa program to prevent aging-related conditions in metabolic, cardio-vascular, and neurological states. Spa programs modify diet, physical activity, and lymphatic drainage, as it deteriorates with aging. We investigated its influence on the blood markers of biological age of patients during their stay to objectify the potential of spa treatment for influencing the risk of age-related events.

Model of two competing populations in two habitats with migration: Application to optimal marine protected area size.

The standard model of a single population fragmented into two patches connected by migration, was first introduced in the 1970s by Freedman and Waltman, since generating long-term research interest, though its full analysis for arbitrary values of migration rate has only been completed relatively recently. Here, we present a model of two competing species in a two-patch habitat with migrations between patches. We derive equilibrium solutions of this model for three cases of migration rate resulting in isolated, well-mixed and semi-isolated habitats.

The new differential diagnostic test for the lichenoid drug eruption.

The differential diagnosis between lichenoid drug eruption (LDE) and lichen planus (LP) is difficult due to similar clinical and histological signs but important for treatment and prognosis. The purpose of this study was to propose the new diagnosis method for differentiate LDE from LP. During 2015-2018, 20 patients with confirmed LDE, 13 patients with LP and 134 controls were examined and treated at the Lenoblcenter.

Ecological costs of climate change on marine predator-prey population distributions by 2050.

Identifying and quantifying the effects of climate change that alter the habitat overlap of marine predators and their prey population distributions is of great importance for the sustainable management of populations. This study uses Bayesian joint models with integrated nested Laplace approximation (INLA) to predict future spatial density distributions in the form of common spatial trends of predator-prey overlap in 2050 under the "business-as-usual, worst-case" climate change scenario. This was done for combinations of six mobile marine predator species (gray seal, harbor seal, harbor porpoise, common guillemot, black-legged kittiwake, and northern gannet) and two of their common prey species (herring and sandeels).

Bayesian joint models with INLA exploring marine mobile predator-prey and competitor species habitat overlap.

Understanding spatial physical habitat selection driven by competition and/or predator-prey interactions of mobile marine species is a fundamental goal of spatial ecology. However, spatial counts or density data for highly mobile animals often (1) include excess zeros, (2) have spatial correlation, and (3) have highly nonlinear relationships with physical habitat variables, which results in the need for complex joint spatial models. In this paper, we test the use of Bayesian hierarchical hurdle and zero-inflated joint models with integrated nested Laplace approximation (INLA), to fit complex joint models to spatial patterns of eight mobile marine species (grey seal, harbor seal, harbor porpoise, common guillemot, black-legged kittiwake, northern gannet, herring, and sandeels).

[Individual learning curves for microsurgical myocardial revascularization].

Aim: To create individual learning curves for microsurgical myocardial revascularization.

Material And Methods: It was analyzed duration of the individual stages of the first 100 CABG procedures which were performed using microsurgical technique and surgical microscope. Graphs reflecting correlation between duration of the individual surgical stages and their number were framed.

Does increasing mortality change the response of fish populations to environmental fluctuations?

Fluctuations of fish populations abundances are shaped by the interplay between population dynamics and the stochastic forcing of the environment. Age-structured populations behave as a filter of the environment. This filter is characterised by the species-specific life cycle and life-history traits.

[Dynamics of a green oak moth population: application of discrete-continuous models with a nonmonotone density-dependent birth rate].

Considered is a mathematical model for dynamics of an isolated population with non-overlapping generations. The individuals' birth process (emergence of new-generation individuals) is assumed to have a discrete nature (there exist some fixed time moments at which the new generations emerge), while the death process is assumed to be continuous. In addition, the birth rate is assumed to be a function of the number of individuals survived till the moment of reproduction, the function being non-monotone: there exists an optimal value of the population size at which the birth rate reaches its maximum (Alley principle).

Sildenafil inhibits hypoxia-induced pulmonary hypertension.

Background: This study investigated the effect of the phosphodiesterase 5 inhibitor sildenafil on the pulmonary vascular response to hypoxia in humans and mice.

Methods And Results: In a randomized, double-blind study, sildenafil 100 mg or placebo was given orally to 10 healthy volunteers 1 hour before breathing 11% O(2) for 30 minutes. Pulmonary artery pressure (PAP) was measured with an indwelling right heart catheter.

[Characteristics of pneumonia in patients with pulmonary tuberculosis].

In healed tuberculosis, pneumonia more frequently arises in the zones of pronounced residual changes. In active tuberculosis combination of tuberculosis with pneumonia often takes place in intact bronchopulmonary segments. Pneumonia in tuberculous patients takes a lingering course in the presence of pneumosclerotic changes in the lungs, tends to acquire bronchial forms, is characterized by slow involution of inflammation, runs atypically in combination of pneumosclerotic changes in the lungs, bronchial stenoses and abnormal cell composition of bronchoalveolar washout.

[Effectiveness of the treatment of patients with fibrous-cavernous pulmonary tuberculosis].

The follow-up of 301 patients with fibrous-cavernous pulmonary tuberculosis has demonstrated that the disease outcome and treatment effectiveness depend on the nature of its course. A long-term specific therapy for 9-10 months brings about cessation of bacillary excretion in 50-60% of cases even in a progressive course of the disease and closure of destruction cavities occurred in 12.5% of cases with rapid progression and in 21.

[The bacterial excretion dynamics of patients with fibrous-cavernous pulmonary tuberculosis].

A study of 294 patients with fibrous-cavernous pulmonary tuberculosis revealed that massive bacteria elimination and drug polyresistance is found in patients with advancing and complicated course of the disease. It was established that after a nine-months course of treatment bacteria elimination was observed in 50% of patients with advancing fibrous-cavernous pulmonary tuberculosis.

[Variants of the course of fibrous-cavernous pulmonary tuberculosis].

Taking into account the presence of the process development symptoms or their absence (including a high rate of exacerbations, ongoing dissemination process, formation of new cavities in the affected foci, severe infiltration of the lung tissue and massive bacillary excretion), process development rate and the nature of complications, the following 4 versions of fibrous-cavernous pulmonary tuberculosis were identified: rapidly developing disease; slowly developing disease; fibrous-cavernous pulmonary tuberculosis whose clinical picture was determined by different complications; and relatively stable condition. ++Clinico-roentgenological+ features of each version of the disease are described. Abnormalities in the ++clinico-roentgenological+ picture and laboratory findings are especially apparent in patients with rapidly developing fibrous-cavernous pulmonary tuberculosis.

[The results of treating fibrous-cavernous tuberculosis in patients with different genetic markers].

Overall 221 patients with fibrous-cavernous tuberculosis were examined. In patients carrying Hp 2-2 haptoglobin and HLA DR2, the disease runs an unfavourable course more frequently. Among the patients with Hp 2-2, the positive dynamics was attained by the 6th month of the treatment in 44.

[Effect of Argiope lobata venom and its components on L[3H)glutamate binding with locust muscle membranes].

The Argiope lobata venom is shown to block synaptic potential at locust neuromuscular junctions and inhibit the high-affinity sodium independent L[3H]glutamate binding site in locust muscle membranes. The data obtained due to fractionation of venom evidence that it contains components which block synaptic potential and inhibit the binding of L[3H]glutamate (5 kDa and more) as well as components which block synaptic potential but do not inhibit the binding of L[3H]glutamate less than 5 kDa. These observations indicate that spider venom contains at least two components with different mechanism of action.