Effect of chronic administration and withdrawal of caffeine on motor function, cognitive functions, anxiety, and the social behavior of BLC57 mice.

Objectives: The cognitive functions, motor coordination, and social behavior were studied in rodents after adding different doses of caffeine in their drinking water.

Methodology: BLC57 mice were divided into four groups: Control ( = 8), chronic moderate dose ( = 8, Ch] MD), Ch high dose ( = 8, Ch HD), and withdrawal ( = 8, WD). Caffeine was administered for 1 month to all groups.

Acute Administration of Caffeine: The Effect on Motor Coordination, Higher Brain Cognitive Functions, and the Social Behavior of BLC57 Mice.

Excessive caffeine consumption causes adverse health effects. The effects of moderate and high doses of caffeine consumption on the motor coordination, cognitive brain functions, and the social behavior in mice were studied. Animals were divided into three groups: control group, moderate dose group (Ac MD), and high dose group (Ac HD).