Publications by authors named "Sadichhya Karki"
Introduction: Transcatheter mitral valve-in-valve replacement (TMVR ViV) is becoming a favorable, less invasive procedure among high-risk patients to manage mitral valve dysfunction. We aimed to investigate the trends of the predictors and outcomes of the procedure.
Methods: The national inpatient sample databases of 2016-2020 were analyzed using STATA 17 software and ICD-10 codes for TMVR ViV, with stratification for mitral stenosis (MS) or Mitral regurgitation (MR) as etiology for prosthetic valve dysfunction.
Article Synopsis
- Familial hypercholesterolaemia (FH) is linked to an increased risk of heart disease, particularly in patients who experience acute myocardial injury (AMI), but detailed outcomes for these patients have been understudied.
- The research analyzed data from US hospitals between 2018 and 2020, focusing on adults with AMI to compare outcomes based on the presence of FH.
- Findings revealed that FH patients had higher rates of ST-elevation and non-ST-elevation myocardial infarctions, required more invasive procedures, but exhibited lower all-cause mortality and lower incidences of type 2 MI and takotsubo cardiomyopathy compared to those without FH.
Article Synopsis
- Chest radiotherapy (C-XRT) can lead to complications such as aortic stenosis, which often necessitates transcatheter aortic valve replacement (TAVR), but data on outcomes for C-XRT survivors are limited.
- A national inpatient study from 2016 to 2020 identified 515 patients with a history of C-XRT who underwent TAVR, comparing their outcomes to matched controls without C-XRT.
- The results indicated that C-XRT patients had lower in-hospital mortality, shorter hospital stays, reduced total charges, and fewer complications, highlighting a potential advantage in TAVR outcomes for these patients.
Albumin is a protein produced by the liver essential for maintaining blood volume and regulating fluid balance. Hypoalbuminemia is characterized by low levels of albumin in the blood. It is also a marker of malnutrition-inflammatory syndrome.
View Article and Find Full Text PDFRegorafenib is an oral multi-kinase inhibitor that is used in the treatment of chemotherapy-resistant metastatic colorectal carcinoma. However, multi-kinase inhibitors have been known to cause cardiac side effects, most notably hypertension. Myocardial ischemia is a very extraordinary adverse effect of regorafenib.
View Article and Find Full Text PDFIn patients hospitalized for infective endocarditis (IE), timing of nonurgent transesophageal echocardiography (TEE) to reduce embolic events (EE) is unclear. In a retrospective cohort from the 2016 to 2018 combined National Inpatient Sample (NIS), Low-risk adults with IE who underwent nonurgent (>48 hours) TEE were stratified into 3 cohorts based on the timing of the first TEE: early-TEE (3-5 days), intermediate-TEE (5-7 days) and late-TEE (>7). The primary outcome was a composite of an embolic event.
View Article and Find Full Text PDFBackground: Hyponatremia is associated with negative prognosis in several conditions like Congestive heart failure and acute MI (Myocardial Infarction), but its impact on the outcomes in patients with pulmonary embolism (PE) is not well studied. We aimed to study the association of hyponatremia in patients hospitalized with PE.
Methods: A retrospective cohort study was designed using data obtained from the 2016 to 2019 combined National Inpatient Sample (NIS) database.