Redirecting Cisplatin and Doxorubicin to Mitochondria Affords Highly Effective Platinum Prodrug Against Triple Negative Breast Cancer.

A mitochondria targeting dual-action platinum prodrug exhibits high anticancer activity in triple negative breast cancer cells. The complex intervenes in several cellular processes including DNA damage, perturbation of mitochondrial bioenergetics and induction of necrosis to kill cancer cells.

Multiaction Platinum(IV) Prodrug Containing Thymidylate Synthase Inhibitor and Metabolic Modifier against Triple-Negative Breast Cancer.

Multifunctional platinum anticancer prodrugs have the potential to enrich the anticancer properties and overcome the clinical problems of drug resistance and side effects of platinum anticancer agents. Herein, we develop dual and triple action platinum complexes with targeted and biological active functionalities. One complex () that consists of cisplatin, tegafur, and lonidamine exhibits strong cytotoxicity against triple negative breast cancer (TNBC) cells.

Titanium oxide-bacterial cellulose bioadsorbent for the removal of lead ions from aqueous solution.

In the current study, nanocomposites of bacterial cellulose (BC) and amorphous TiO were prepared and characterized. The nanocomposites were evaluated as adsorbent for the removal of lead (Pb) from aqueous solution. The different reactions conditions such as pH, equilibrium time, temperature, adsorbent dose and possible recycling of adsorbent were studied.

Biotin-tagged platinum(iv) complexes as targeted cytostatic agents against breast cancer cells.

A biotin-guided platinum complex is highly cytotoxic against breast cancer cells but hypotoxic against mammary epithelial cells. The mono-biotinylated Pt complex is superior to the di-biotinylated one and hence a promising drug candidate for the targeted therapy of breast cancer.

Effect of cycle run time of backwash and relaxation on membrane fouling removal in submerged membrane bioreactor treating sewage at higher flux.

Intermittent backwashing and relaxation are mandatory in the membrane bioreactor (MBR) for its effective operation. The objective of the current study was to evaluate the effects of run-relaxation and run-backwash cycle time on fouling rates. Furthermore, comparison of the effects of backwashing and relaxation on the fouling behavior of membrane in high rate submerged MBR.

Perspectives of low cost arsenic remediation of drinking water in Pakistan and other countries.

Arsenic concentrations above acceptable standards for drinking water have been detected in many countries and this should therefore is a global issue. The presence of arsenic in subsurface aquifers and drinking water systems is a potentially serious human health hazard. The current population growth in Pakistan and other developing countries will have direct bearing on the water sector for meeting the domestic, industrial and agricultural needs.