Evaluation of Cognitive levels and Item writing flaws in Medical Pharmacology Internal Assessment Examinations.

Objectives: This study aimed to evaluate the cognitive levels of Multiple Choice Questions (MCQs) & Short Answer Questions (SAQs) and types of Item Writing Flaws (IWFs) in MCQs in Medical Pharmacology internal assessment exams.

Methods: This descriptive, study was conducted over a period of six months, from December 2015 to May 2016 and evaluated six internal assessment examinations comprising SAQs and MCQs. A total of 150 MCQs and 43 SAQs were analyzed.

Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss.

Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD(+)) exhibits axon-protective effects in cultured neurons; however, its ability to block degeneration in vivo has been difficult to establish due to its poor cell permeability and serum instability. Here, we describe a strategy to increase cochlear NAD(+) levels in mice by administering nicotinamide riboside (NR), a recently described NAD(+) precursor.