Immobilization stress exacerbates arsenic-induced reprotoxic effects in adult rats.

Objective: The central objective of this study was to investigate the cumulative effects restraint stress and sodium arsenite on reproductive health in male rats.

Methods: Healthy male Wistar rats were allocated into 4 groups ( = 8). Animals in group 1 served as controls and did not subjected to any stress.

α-Lipoic acid inhibits testicular and epididymal oxidative damage and improves fertility efficacy in arsenic-intoxicated rats.

The present study evaluates the protective effect of α-lipoic acid (LA) against arsenic-induced testicular and epididymal oxidative damage in rats. Arsenic caused significant reduction in the reproductive organ weights, serum testosterone levels, testicular daily sperm count, epididymal sperm count, sperm motility, sperm viability, and sperm membrane integrity. Significant reduction in the activity levels of superoxide dismutase, catalase, and glutathione levels with a concomitant increase in the lipid peroxidation and protein carbonyl content in the testis and the cauda epididymis of arsenic-exposed rats.