Publications by authors named "Sadeghirad Behnam"
Background: Increasing evidence has emerged for traditional, complementary and integrative medicine (TCIM) to treat COVID-19 which requires systematic summaries of the net benefits of interventions against standard care and one another. The study aims to conduct a systematic review and network meta-analysis (NMA) regarding TCIM therapies for treating mild/moderate acute COVID-19, potentially informing the WHO guideline development and clinical decision-making.
Methods And Analysis: We will search Embase, MEDLINE, Virtual Health Library on Traditional Complementary and Integrative Medicine, Cochrane Central Register of Controlled Trials, WHO's International Clinical Trials Registry Platform with additional searches of Chinese and Korean literature sources for randomised controlled trials comparing TCIM with placebo, standard care, no treatment or with an alternate type of TCIM to treat COVID-19.
Publisher Correction: Health Technology Assessment Reports for Non-Oncology Medications in Canada from 2018 to 2022: Methodological Critiques on Manufacturers' Submissions and a Comparison Between Manufacturer and Canadian Agency for Drugs and Technologies in Health (CADTH) Analyses.
Pharmacoecon Open
November 2024
Introduction: Identifying key differences between manufacturers' submitted analysis and economic reanalysis by the Canadian Agency for Drugs and Technologies in Health (CADTH) is an important step toward understanding reimbursement recommendations. We compared economic values reported in manufacturers' analysis with the CADTH reanalysis and also assessed methodological critiques.
Methods: Two reviewers extracted data from the clinical and economic reports in publicly available CADTH reports from 2018 to 2022.
Objectives: To assess the efficacy and safety of pharmacological interventions for preventing upper gastrointestinal (GI) bleeding in people admitted to intensive care units (ICUs).
Design And Setting: Systematic review and frequentist network meta-analysis using standard methodological procedures as recommended by Cochrane for screening of records, data extraction and analysis. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of evidence.
Article Synopsis
- Researchers wanted to find out which method of helping people breathe (called the Spontaneous Breathing Trial, or SBT) worked best for those who are really sick and need help with breathing tubes.
- They looked at a bunch of studies involving over 6,700 patients to compare different SBT methods, focusing on how well they helped people breathe on their own without needing tubes again.
- Results showed that methods using support like Pressure Support (PS) and Automatic Tube Compensation (ATC) were better at helping patients breathe and stay off the breathing tubes compared to a method called T-piece, but some of these methods had a higher chance of needing to put the tube back in.
Article Synopsis
- The study investigates the best empiric antibiotic treatments for non-ventilator-associated hospital-acquired pneumonia (HAP) through a network meta-analysis of randomized controlled trials (RCTs).
- It analyzed data from 39 RCTs with a total of 4,807 participants, suggesting that piperacillin-tazobactam and carbapenems may be more effective at reducing treatment failure compared to cephalosporins, though the certainty of this evidence is low.
- Additionally, the analysis indicated that a combination of ceftazidime and linezolid did not significantly differ from using cephalosporins alone in terms of reducing all-cause mortality, also reflecting low
Objective: To assess the effectiveness of mesenchymal stem cells (MSCs) for chronic knee pain secondary to osteoarthritis (OA).
Methods: We searched MEDLINE, EMBASE, CINAHL, and Cochrane Central to September 2023 for trials that (1) enrolled patients with chronic pain associated with knee OA, and (2) randomized them to MSC therapy vs. placebo or usual care.
Evidence regarding the comparative efficacy of the different methods to determine the significance of coronary stenoses in the catheterization laboratory is lacking. We aimed to compare all available methods guiding the decision to perform percutaneous coronary intervention (PCI). We searched Medline, Embase, and CENTRAL until October 5, 2023.
View Article and Find Full Text PDFArticle Synopsis
- Chronic postsurgical pain (CPSP) is a common issue following musculoskeletal and orthopedic surgeries and significantly affects patients' quality of life, leading to a need for effective preventive interventions.
- This study will conduct a systematic review and network meta-analysis of randomized trials to evaluate the effectiveness and potential harms of various pharmacological and psychological treatments aimed at preventing CPSP.
- The research will involve thorough searches of multiple medical databases, focusing on trials that include adults undergoing relevant surgeries, with outcomes measured at least three months post-operation, and will also explore factors like sex and surgery type to assess any specific treatment effects.
Comparison of safety and effectiveness of antiretroviral therapy regimens among pregnant women living with HIV at preconception or during pregnancy: a systematic review and network meta-analysis of randomized trials.
BMC Infect Dis
April 2024
Background: Mother-to-child transmission is the primary cause of HIV cases among children. Antiretroviral therapy (ART) plays a critical role in preventing mother-to-child transmission and reducing HIV progression, morbidity, and mortality among mothers. However, after more than two decades of ART during pregnancy, the comparative effectiveness and safety of ART medications during pregnancy are unclear, and existing evidence is contradictory.
View Article and Find Full Text PDFBackground: Cognitive behavioural therapy (CBT) has been shown to be effective for several psychiatric and somatic conditions; however, most randomized controlled trials (RCTs) have administered treatment in person and whether remote delivery is similarly effective remains uncertain. We sought to compare the effectiveness of therapist-guided remote CBT and in-person CBT.
Methods: We systematically searched MEDLINE, Embase, PsycINFO, CINAHL, and the Cochrane Central Register of Controlled Trials from inception to July 4, 2023, for RCTs that enrolled adults (aged ≥ 18 yr) presenting with any clinical condition and that randomized participants to either therapist-guided remote CBT (e.
Objectives: Assessment of the certainty of evidence (CoE) from network meta-analysis is critical to convey the strength of inferences for clinical decision-making. Both the GRADE (Grading of Recommendations Assessment, Development and Evaluation) Working Group (GWG) and the Confidence in Network Meta-Analysis (CINeMA) framework have been designed to assess the CoE of treatment effects informed by network meta-analysis; however, the concordance of results is uncertain.
Study Design And Setting: We assessed the CoE for treatment effects of individual opioids on pain relief and physical functioning from a network meta-analysis for chronic noncancer pain using the GWG approach and the CINeMA framework.
Article Synopsis
- A systematic review and network meta-analysis was conducted to compare the effectiveness and safety of different intravenous medications used for procedural sedation and analgesia in emergency departments and ICUs.
- The analysis included 82 randomized controlled trials involving over 8,000 patients and focused on sedation recovery time, patient satisfaction, and adverse events related to the medications.
- Results showed that propofol had a shorter recovery time than midazolam-opioids, while ketamine-propofol combinations improved patient satisfaction; however, certain adverse events varied by medication combinations.
Article Synopsis
- Some recent studies found that benzodiazepines might help prevent nausea and vomiting after surgery, but doctors haven't added them to the official guidelines yet because they worry about side effects.
- Researchers reviewed lots of studies and found that using benzodiazepines before or after surgery can lower the chances of feeling sick or throwing up.
- The results from this research will help update future guidelines for doctors on how to prevent nausea and vomiting after surgery.
Objective: The objective of this study is to evaluate the comparative benefits and harms of opioids and cannabis for medical use for chronic non-cancer pain.
Design: Systematic review and network meta-analysis.
Data Sources: EMBASE, MEDLINE, CINAHL, AMED, PsycINFO, PubMed, Web of Science, Cannabis-Med, Epistemonikos and the Cochrane Library (CENTRAL) from inception to March 2021.
Article Synopsis
- The text discusses the effectiveness of various therapies for chronic pain related to temporomandibular disorders (TMD), which impact a significant percentage of adults worldwide.
- Current guidelines for treating TMD are primarily based on consensus, leading to inconsistent recommendations across the board.
- Strong recommendations favor cognitive behavioral therapy and physical interventions like supervised exercises, while conditional recommendations address a mix of both supportive and discouraged treatments, such as acupuncture and the use of certain medications.
Objective: We explored the comparative effectiveness of available therapies for chronic pain associated with temporomandibular disorders (TMD).
Design: Systematic review and network meta-analysis of randomised clinical trials (RCTs).
Data Sources: MEDLINE, EMBASE, CINAHL, CENTRAL, and SCOPUS were searched to May 2021, and again in January 2023.
Article Synopsis
- Postoperative delirium (POD) is a serious complication affecting nearly 1 in 5 patients after noncardiac surgery, with various preoperative and perioperative factors influencing its risk.
- A comprehensive analysis included data from 21 studies with over 8,000 patients to identify which risk factors significantly contribute to the development of POD.
- Key risk factors for POD identified include older age, higher ASA status, low body mass index, history of delirium, preoperative cognitive impairment, and elevated C-reactive protein levels.
Importance: Modulation of intestinal microbiome by administering probiotics, prebiotics, or both may prevent morbidity and mortality in premature infants.
Objective: To assess the comparative effectiveness of alternative prophylactic strategies through a network meta-analysis (NMA) of randomized clinical trials.
Data Sources: MEDLINE, EMBASE, Science Citation Index Expanded, CINAHL, Scopus, Cochrane CENTRAL, and Google Scholar from inception until May 10, 2023.
Article Synopsis
- Atopic dermatitis (AD) is a widespread skin condition treated with various topical prescriptions, but their comparative effectiveness is not well known.
- A systematic review of randomized trials was conducted to evaluate the benefits and harms of topical treatments for AD, employing rigorous analysis and classification methods.
- High-certainty evidence showed that pimecrolimus and high-dose tacrolimus were highly effective, while group 5 topical corticosteroids (TCS) also significantly aided in managing AD without increasing harm.
Background: Treatment failure is considered to be an important factor in relation to the increase in scabies incidence over the last decade. However, the regional and temporal differences, in addition to the predictors of therapy failure, are unclear.
Objectives: We aimed to conduct a systematic review of the prevalence of treatment failure in patients with scabies and investigation of associated factors.
American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: methodology and review of evidence.
Gastrointest Endosc
September 2023
This document from the American Society for Gastrointestinal Endoscopy (ASGE) provides a full description of the methodology used in the review of the evidence used to inform the final guidance outlined in the accompanying Summary and Recommendations document regarding the role of endoscopic submucosal dissection (ESD) in the management of early esophageal and gastric cancers. This guideline used the Grading of Recommendations, Assessment, Development and Evaluation framework and specifically addresses the role of ESD versus EMR and/or surgery, where applicable, for the management of early esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), and gastric adenocarcinoma (GAC) and their corresponding precursor lesions. For ESCC, the ASGE suggests ESD over EMR for patients with early-stage, well-differentiated, nonulcerated cancer >15 mm, whereas in patients with similar lesions ≤15 mm, the ASGE suggests either ESD or EMR.
View Article and Find Full Text PDFBackground: Postoperative delirium (POD) is a frequent complication in older adults, characterised by disturbances in attention, awareness and cognition, and associated with prolonged hospitalisation, poor functional recovery, cognitive decline, long-term dementia and increased mortality. Early identification of patients at risk of POD can considerably aid prevention.
Methods: We have developed a preoperative POD risk prediction algorithm using data from eight studies identified during a systematic review and providing individual-level data.