Publications by authors named "Sadeghi-Nejad H"

Background: Inflatable penile prosthesis (IPP) insertion is recommended for the treatment of patients with Peyronie's disease (PD) and significant erectile dysfunction (ED); adjunctive procedures can be used for residual curvature after IPP placement.

Aim: To assess the management of penile curvature correction in PD patients undergoing IPP procedures within a large multinational, multicenter cohort.

Methods: A retrospective analysis was conducted on PD patients treated with IPP by 11 experienced prosthetic surgeons.

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Purpose: Surgical resident autonomy in procedures has been eroding over time, due to multiple factors that include duty hour restrictions, focus on operating time, complication rate, and trust among supervising physicians. This study examines whether urology residents at the Veterans Affairs hospitals (VA) have experienced decreased surgical autonomy and contributing factors.

Methods: The national VA Surgical Quality Improvement Program (VASQIP) was queried for the most common urologic procedures between 2004 to 2019 with resident involvement.

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Article Synopsis
  • The study aimed to analyze pre- and intraoperative factors influencing the integrity of corporal bodies after placing an inflatable penile prosthesis (IPP), focusing on the occurrence of intraoperative and postoperative complications.
  • Researchers reviewed a database of over 5,400 IPP surgeries conducted between 2016 and 2021, identifying significant predictors for complications linked to corporal integrity.
  • Key predictors for complications included revision surgery, older age, and medical conditions like coronary artery disease or peripheral vascular disease, indicating the need for consideration of these factors during IPP placement to reduce risks.
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  • Patients with urologic conditions, like Peyronie's disease, are increasingly seeking health information online despite having access to clinicians through electronic health records.
  • The study aimed to evaluate the quality, accuracy, and readability of information provided by four large language model (LLM) chatbots, particularly in response to specific patient queries about Peyronie's disease.
  • Results indicated that unprompted responses from LLMs were of moderate quality but improved to high quality when prompted; however, the reading level of responses was too complex for general understanding, averaging at a grade 12.9 level.
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The Princeton Consensus (Expert Panel) Conference is a multispecialty collaborative symposium dedicated to optimizing sexual function and preserving cardiovascular health. The Fourth Princeton Consensus Conference was convened on March 10-11, 2023, at the Huntington Medical Research Institutes in Pasadena, California. Princeton panels I to III addressed the clinical management of men with erectile dysfunction (ED) who also had cardiovascular disease.

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Article Synopsis
  • - The study aimed to identify factors influencing the length of penile implants in men undergoing primary inflatable penile prosthesis (IPP) placement at multiple surgical centers from July 2016 to July 2021.
  • - Findings revealed that older age, Asian ethnicity, history of radical prostatectomy, and the infrapubic surgical approach were linked to shorter implant lengths, while Black or African American ethnicity was associated with longer implants.
  • - Understanding these associations can help doctors better counsel patients about potential implant lengths and set realistic expectations for postoperative outcomes.
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Introduction: Prior consensus meetings have addressed the relationship between phosphodiesterase type 5 (PDE5) inhibition and cardiac health. Given significant accumulation of new data in the past decade, a fourth consensus conference on this topic was convened in Pasadena, California, on March 10 and 11, 2023.

Objectives: Our meeting aimed to update existing knowledge, assess current guidelines, and make recommendations for future research and practice in this area.

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  • A study was conducted to investigate how climate variations influence the risk of infections in patients receiving inflatable penile prosthesis (IPP) surgery across multiple international medical centers.
  • The research analyzed data from 5,289 patients, finding no statistically significant correlation between the season or month of surgery, daily temperature, humidity, or dew point, and the occurrence of infections, which were relatively low at 1.9%.
  • The results suggest that urologists don't need to adjust infection prevention strategies based on climate conditions when performing IPP surgeries.
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Purpose: The purpose of this white paper is to educate health care professionals about the evolution of telemedicine (TM) and to propose a hybrid model that leverages the strengths of traditional in-person medicine as well as virtual medicine while maximizing the safety and quality of men's sexual health care.

Literature Search Strategy: A literature search focused on the use of TM in urology and men's health was performed through PubMed/MEDLINE, Embase, and Web of Science (January 1, 2012-April 26, 2022). Keywords included all known permutations of the terminology used to refer to virtual health, care as well as the terminology used to refer to urologic diseases, issues specific to men's health, and men's sexual health concerns.

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-Obesity is a prevalent health concern that notably impairs male fertility through hormonal disruptions and other pathophysiological alterations. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can significantly reduce weight. This narrative review synthesizes the existing literature discussing the impact of glucagon-like peptide-GLP-1 RAs on the male reproductive system, particularly on the hypothalamic-pituitary-gonadal axis and spermatogenesis, highlighting their potential impact on male fertility.

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Background: In 1999, 1 year after the approval of the first oral phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED), the first Princeton Consensus Conference was held to address the clinical management of men with ED who also had cardiovascular disease. These issues were readdressed in the second and third conferences. In the 13 years since the last Princeton Consensus Conference, the experience with PDE5 inhibitors is more robust, and recent new data have emerged regarding not only safety and drug-drug interactions, but also a potential cardioprotective effect of these drugs.

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Objective: To assess the difference in outcomes between single dilation (SingD) and sequential dilation (SeqD) in primary penile implantation, hypothesizing that patients who undergo SeqD had higher rates of noninfectious complications.

Methods: We performed a multicenter, retrospective study of men undergoing primary inflatable penile prosthesis placement. Intraoperative complications and postoperative noninfectious outcomes were assessed between the two groups.

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Background: Corporal fibrosis is known to result from prolonged priapism; however, the impact of the timing of penile prosthesis placement after priapism on complication rates is poorly understood.

Aim: We sought to evaluate the impact of timing of inflatable penile prosthesis (IPP) placement on complications in men with a history of ischemic priapism.

Methods: We performed a multicenter, retrospective cohort study of patients with a history of priapism undergoing IPP placement by 10 experienced implantation surgeons.

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Purpose Of Review: This paper aims to survey current literature on urologic graduate medical education focusing on surgical autonomy.

Recent Findings: Affording appropriate levels of surgical autonomy has a key role in the education of urologic trainees and perceived preparedness for independent practice. Recent studies in surgical resident autonomy have demonstrated a reduction in autonomy for trainees in recent years.

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Purpose: Our aim was to determine if the AUA-recommended prophylaxis (vancomycin + gentamicin alone) for primary inflatable penile prosthesis surgery is associated with a higher infection risk than nonstandard regimens.

Materials And Methods: We performed a multicenter, retrospective study of patients undergoing primary inflatable penile prosthesis surgery. Patients were divided into those receiving vancomycin + gentamicin alone and those receiving any other regimen.

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Peyronie's disease (PD) is a fibrotic disorder of the tunica albuginea that may result in penile deformity, pain, a palpable plaque, and erectile dysfunction. In order to understand the psycho-sexual impacts of PD on patients and their partners, we selected three online forums containing the largest number of threads on PD. Threads focusing on the psycho-sexual impacts posted from January 1, 2011 to January 1, 2021 were compiled, and thematic analysis was performed on Dedoose.

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Purpose: The prevalence of erectile dysfunction (ED) and the utilization of inflatable penile prosthesis (IPP) among prostate cancer patients are understudied. The aim of the study was to examine the relationships between ED, prostate cancer treatment type and IPP implantation in a national cohort.

Materials And Methods: We identified a retrospective cohort of Surveillance, Epidemiology, and End Results (SEER)-Medicare patients diagnosed with locoregional prostate cancer between 2006 and 2011 and treated with surgery or radiation.

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Objective: To examine stakeholder perspectives regarding the lack of in-person externships and transition to a virtual urology residency interview format. The unprecedented disruption from the COVID-19 pandemic forced an abrupt pivot to a "virtual" Urology Match for the 2021 cycle. We aim for our study to inform ongoing deliberations on the future of the Urology Match.

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Article Synopsis
  • YouTube is a popular but unregulated platform where patients often seek information about treatment options for male hypogonadism and testosterone therapy.
  • A study analyzed 80 YouTube videos related to these topics, focusing on their reliability measured by view counts and the DISCERN score, particularly comparing videos featuring board-certified physicians to those without.
  • Results showed that while the majority of videos were deemed unreliable, those created by physicians tended to be more reliable despite having fewer views; this highlights the need for physicians and academic societies to produce verified content to better inform patients.
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Introduction: YouTube is the most used social media website, and there is a growing body of literature examining the reliability of healthcare information on this platform. Patients seeking men's health information may be more likely to use YouTube owing to the sensitivity of these issues.

Objectives: The objective of this study is to review the literature for studies related to the reliability of YouTube videos about men's health topics.

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Purpose: We examined whether patients are appropriately screened for previous prolonged erections or priapism and counseled about trazodone complications, specifically prolonged erections and priapism, prior to trazodone treatment.

Materials And Methods: We identified patients under the age of 50 on trazodone as of February 27, 2019 at the VA New Jersey Health Care System. Patients were asked about information provided to them prior to medication initiation, occurrence of prolonged erections/priapism, and reporting rate of side effects.

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Introduction: Pharmacologically induced priapism is now the most common cause of priapism, with approximately 50% of drug-related priapism being attributed to antipsychotic usage. The majority of pharmacologic priapism is believed to result in ischemic priapism (low flow), which may lead to irreversible complications, such as erectile dysfunction. It is imperative that prescribing physicians be aware of potentially inciting medications.

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