Identification of functional missense single-nucleotide polymorphisms in in a predominantly Hispanic population.

Background: Tumor necrosis factor alpha-induced protein 3 () is a multifunctional ubiquitin binding and editing enzyme that regulates inflammation. Genetic studies have implicated polymorphisms within the locus to the development of numerous immune-related diseases. This study evaluated the frequencies of single nucleotide polymorphism (SNPs) within the exonic regions of the gene and an associated point mutation from the Illumina array among a predominantly Hispanic cohort.