Effective methods for the decontamination of healthcare waste: Ozone and UV-C radiation process.

Human-generated waste, including infectious healthcare waste, poses significant risks to public health and the environment. The COVID-19 pandemic has increased the global production of infectious waste, emphasizing the need for safe and sustainable waste management practices. While autoclaves are commonly used for on-site disposal, alternative methods like ozone gas and UV-C radiation offer environmentally friendly options that effectively eliminate pathogens without leaving toxic residues.

The concentration of pesticides in tomato: a global systematic review, meta-analysis, and health risk assessment.

To improve farming productivity, a large number of pesticides have been used worldwide in recent decades, leading to the pollution of soil, agri-products, and water, directly/indirectly affecting human health. In this regard, many studies were conducted in different countries on residual pesticides in the environment. In the current study, residual pesticides including chlorpyrifos, cypermethrin, diazinon, malathion, and metalaxyl in tomatoes were meta-analyzed and health risk of consumers was estimated.

Enhancing anaerobic digestion of automotive paint sludge through biochar addition.

The reduction of traditional fuel sources and the unpredictability of the global economy have led to a push for renewable energy alternatives. Waste recycling can significantly reduce greenhouse gas emissions. In this study, the effects of different proportions of biochar on the efficiency of mesophilic anaerobic digestion of automotive paint sludge were investigated over a period of one month.

Simultaneous Cr (VI) reduction and diazinon oxidation with organometallic sludge formation under photolysis: kinetics, degradation pathways, and mechanism.

In this study, simultaneous removal of an organic matter (diazinon, DIZ) and an inorganic substance (chromium, Cr) was used. Breaking down of organic matter by UV irradiation produces various radicals, including sulfides, carboxyl, hydroxyl, hydrated electrons, and various organic radicals that are highly reactive and help us to precipitation inorganic substance (Cr). The optimal condition was 30:1 DIZ:Cr molar ratio, pH 9, and about 100% and 82.

Enhanced adsorption and recyclability of surface modified hydrophobic silica aerogel with triethoxysilane: removal of cefixime by batch and column mode techniques.

Amine modified pumice-derived silica aerogel (AMPDSA) was synthesized and grafted up to 6.52 [Formula: see text] with (3-aminopropyl) triethoxysilane for cefixime antibiotic adsorption. Using Response surface methodology, at the pH of 3, the maximum removal of cefixime of 80.

Comparative study of energy consumption, kinetic, and performance between conventional and baffled photocatalytic reactor (BPCR) to ofloxacin photo-degradation.

Regarding the cost-effective photo-degradation of ofloxacin (OFL), present study investigates UV/sulfite /ZnO (USZ) in reactor conventional (without baffles) and baffled photocatalytic reactor (BPCR). The optimal condition was 0.77:2:50 sulfite/ZnO/OFL molar ratio, pH 7, and 30 min reaction time for 100% degradation of 200 mg L concentration of OFL.

A systematic review and meta-analysis of human biomonitoring studies on exposure to environmental pollutants in Iran.

Population exposure to environmental contaminants can be precisely observed through human biomonitoring studies. The present study aimed to systematically review all the biomonitoring studies conducted in Iran on some selected carcinogen environmental pollutants. In this systematic review study, 11 carcinogen agents were selected including arsenic, cadmium, chromium, nickel, lindane, benzene, trichloroethylene (TCE), pentachlorophenol (PCP), radon-222, radium-224, - 226, - 228, and tobacco smoke.

Targeted next generation sequencing directly from sputum for comprehensive genetic information on drug resistant Mycobacterium tuberculosis.

Background: Timely drug resistance detection is essential to global tuberculosis management. Unfortunately, rapid molecular tests assess resistance to only a few drugs, with culture required for comprehensive susceptibility test results.

Methods: We evaluated targeted next generation sequencing (tNGS) for tuberculosis on 40 uncultured sputum samples.

The concentration and probabilistic risk assessment of potentially toxic elements in fillets of silver pomfret (Pampus argenteus): A global systematic review and meta-analysis.

The contamination of fish type products such as silver pomfret fish fillets by potentially toxic elements (PTEs) has raised global health concerns. Related studies regarding the concentration of PTEs in fillets of silver pomfret fish were retrieved among some international databases such as Scopus, PubMed and Embase between 1 January 1983 and 10 March 2020. The pooled (mean) concentration of PTEs in fillets of silver pomfret fish was meta-analyzed with the aid of a random-effect model (REM).

Enhancing photo-degradation of ciprofloxacin using simultaneous usage of e and OH over UV/ZnO/I process: Efficiency, kinetics, pathways, and mechanisms.

The aim of this study is to develop the process relies on the UV irradiation of ZnO and I, i.e. UV/ZnO /I (UZI), to create both oxidizer and reducer agents simultaneously for photo-degradation of the Ciprofloxacin (CIP).

Data on biosurfactant assisted removal of TNT from contaminated soil.

Contamination of environment, especially soil, is in great concern and can cause health problems. Thus, remediation of these pollutants through environmentally friendly methods should be considered. The aim of this data was bioremediation of TNT from contaminated soil.

Evaluation of pyrosequencing for extensive drug resistance-defining anti-tuberculosis drugs for use in public healthcare.

MGIT 960 drug susceptibility testing (DST) for Mycobacterium tuberculosis was compared for performance and speed with pyrosequencing (PSQ). Pulmonary samples (n = 100), from GeneXpert/MTB/Rifampicin-resistant patients receiving second-line treatment for 1-3 months, were subjected to DST and PSQ for seven drugs (isoniazid, rifampicin, kanamycin, amikacin, capreomycin, moxifloxacin, and ofloxacin). The mean time-to-result was 35 and two days for DST and PSQ, respectively.

Kinetic parameters and nitrate, nitrite changes in bioremediation of Toxic Pentaerythritol Tetranitrate (PETN) contaminated soil.

Background: Cleanup of areas contaminated by explosives is a public health concern. Some explosives can be carcinogenic in humans. Pentaerythritol Tetranitrate (PETN), a powerful explosive with very low water solubility, can be easily transported to ground waters.

Predictors of hepatitis C virus recurrence after living donor liver transplantation: Mansoura experience.

Background And Study Aims: Hepatitis C virus (HCV)-related cirrhosis is the leading cause of liver transplantation (LT). All patients who undergo LT with detectable serum HCV-RNA experience graft reinfection, which is the most frequent cause of graft loss and death in these patients. We estimated the rate of HCV recurrence and evaluated the current therapeutic regimens.

Correlating rrs and eis promoter mutations in clinical isolates of Mycobacterium tuberculosis with phenotypic susceptibility levels to the second-line injectables.

Objective/background: The in vitro drug-susceptibility testing of Mycobacterium tuberculosis reports isolates as resistant or susceptible on the basis of single critical concentrations. It is evident that drug resistance in M. tuberculosis is quite heterogeneous, and involves low level, moderate level, and high level of drug-resistant phenotypes.

Redefining MTBDRplus test results: what do indeterminate results actually mean?

Background: Although line-probe assays (LPAs) are promising, little research has been conducted to elucidate the true nature of indeterminate LPA results or assess the ability of these assays to perform on a wide range of clinical samples.

Objective: To evaluate the performance of the commercially available GenoType(®) MTBDRplus LPA against conventional BACTEC™ MGIT™ 960 culture and drug susceptibility testing (DST) among 308 pulmonary tuberculosis (PTB) and 32 extra-pulmonary TB samples.

Results: Invalid LPA results (defined as those with a missing Mycobacterium tuberculosis identification band) were obtained for 18 PTB samples, which were excluded from further analysis.

Defining multidrug-resistant tuberculosis: correlating GenoType MTBDRplus assay results with minimum inhibitory concentrations.

This study correlates MICs of rifampicin (RIF) and isoniazid (INH) with GenoType MTBDRplus assay results for drug-resistant Mycobacterium tuberculosis (MTB) clinical isolates. MICs of RIF and INH were established for 84 and 90 isolates, respectively, testing 7 concentrations of each drug. Genotypic resistance to each drug was determined by GenoType MTBDRplus assay with 50 representative mutations confirmed by pyrosequencing, with mutations in the rpoB gene associated with RIF resistance and mutations in the katG and/or inhA genes associated with INH resistance.

Correlating Minimum Inhibitory Concentrations of ofloxacin and moxifloxacin with gyrA mutations using the genotype MTBDRsl assay.

Objective: To correlate gyrA mutations found on the Genotype MTBDRsl assay in Mycobacterium tuberculosis (MTB) isolates with Minimum Inhibitory Concentrations (MICs) to the fluoroquinolones compounds ofloxacin (OFX) and moxifloxacin (MXF).

Methods: MICs for OFX and MXF were ascertained for 93 archived clinical MTB isolates that showed gyrA mutations at Ala90Val, Ser91Pro, Asp94Ala, Asn/Tyr, Gly and His. Thirty fluoroquinolones susceptible isolates as determined by presence of all wild-type gyrA bands on the Genotype MTBDRsl assay were also included.

Immunochromatographic assays for detection of Mycobacterium tuberculosis: what is the perfect time to test?

In this study, we aimed to correlate the analytical performance of SD BIOLINE TB Ag MPT64 Rapid Test kit (MPT64 assay) with the mycobacterial growth unit (GU) reported by the BACTEC MGIT 960 (MGIT 960) instrument. A total of 394 culture isolates reported positive by MGIT 960 were processed daily (until 'day 4') with the MPT64 assay until a positive MPT64 result was obtained and their GU values were noted daily before MPT64 testing. Based on this correlation of MPT64 positivity and corresponding GU values, a GU cut-off was determined.

Drug resistance patterns in 111 cases of drug-resistant tuberculosis spine.

Purpose: We report the largest study conducted till date of drug resistant tuberculosis in spine analyzing the drug susceptibility patterns in 111 cases of proven drug resistance.

Methods: An observed cross-sectional study was conducted. Six-hundred and eighty-six patients with positive cultures underwent sensitivity testing to 13 commonly used anti-tubercular drugs using BACTEC MGIT-960 system.

Clonal population of Mycobacterium tuberculosis strains reside within multiple lung cavities.

Background: Unsuccessful treatment outcomes among patients with multi-/extensively-drug resistant tuberculosis (TB) have hampered efforts involved in eradicating this disease. In order to better understand the etiology of this disease, we aimed to determine whether single or multiple strains of Mycobacterium tuberculosis (MTB) are localized within lung cavities of patients suffering from chronic progressive TB.

Methodology/findings: Multiple cavity isolates from lung of 5 patients who had undergone pulmonary resection surgery were analyzed on the basis of their drug susceptibility profile, and genotyped by spoligotyping and 24-loci MIRU-VNTR.

Can cord formation in BACTEC MGIT 960 medium be used as a presumptive method for identification of M. tuberculosis complex?

Background: Serpentine cord formation in BACTEC MGIT 960 medium was evaluated as a rapid method for the presumptive identification of M. tuberculosis complex (MTBC).

Material & Methods: Total 2527 samples were processed for AFB culture using MGIT 960 TB system over a period of three months.

Comparison of phenotypic and genotypic methods for pyrazinamide susceptibility testing.

Objectives: To evaluate Pyrazinamide (PZA) susceptibility results obtained by phenotypic MGIT 960 TB system against enzymatic Pyrazinamidase assay and genotypic pncA gene sequencing. To find the prevalence of infections caused by M. bovis in PZA resistant M.