Publications by authors named "Sadaksharam Jayachandran"

In imaging spectroscopy, gathering oral tissue spectral data from resected samples may not accurately represent tissue signatures due to time-dependent changes, blood loss, protein degeneration, and preservation chemicals. In-vivo spectral imaging is employed to address these limitations, but it poses challenges like device dimensions, tissue accessibility, and motion artifacts, impacting data quality and reliability. Our study publishes a dataset of spectral images focusing on oral diseases, addressing these challenges.

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Osteomyelitis is an inflammatory process of both cortical and medullary bone. In the maxillofacial skeleton, it can be seen more commonly in mandible as compared to the maxilla. Here, we present a rare case of osteomyelitis involving the entire maxillae in a 55-year-old male patient highlighting the clinical findings and radiographic features with treatment modalities.

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Context: Age estimation in forensics employ various methods of which Raman microspectroscopy provides a noninvasive method by assessing various parts of dentin.

Aim And Objectives: The aim of this study is to ascertain the age of carious tooth using Raman spectra of apical dentin and to correlate the similarity of the spectra in a defined age group.

Settings And Design: Teeth of known age from Indian population (n=48) and morphology (incisors, canine, premolars, molars) indicated for extraction due to caries were allocated into four groups, i.

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Introduction: This study aimed at comparative analysis of serum nitric oxide (NO) and superoxide dismutase (SOD) levels as therapeutic and prognostic biomarkers in patients with oral submucous fibrosis (OSMF) and squamous cell carcinoma (SCC).

Materials And Methods: Eighty-seven patients were grouped into Group I ( = 29, OSMF), Group II ( = 29, oral SCC), and Group III ( = 29, controls). Two ml of venous blood was collected from patients after overnight fast to avoid any dietary influence on the serum beta-carotene.

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Aim And Objective: To evaluate the therapeutic efficacy of oral pentoxifylline in the treatment of oral submucous fibrosis (OSMF) patients by assessing the clinical symptoms such as burning sensation, mouth opening, and submucosal layer thickness and echogenicity using ultrasonography, both pre- and post-operatively.

Materials And Methods: Thirty study subjects were included in the study and divided into two groups in single-blind randomized manner, oral pentoxifylline and dexamethasone group. Burning sensation, mouth opening, ultrasonographic submucosal thickness, and echogenicity were recorded both pre- and post-operatively.

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Juxtacortical chondrosarcoma (JC) is a rare, malignant, cartilage-forming tumor arising from the external bone surface. It mainly involves long bones and very rarely involves maxillofacial skeleton. Chondrosarcoma in general accounts for about 10-20% of all bone neoplasm, of which only 1-3% is involved in maxillofacial skeleton.

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Inversion has been defined as the malposition of a tooth in which the tooth is reversed and positioned upside down. Very few cases of inverted and impacted third molars have been reported in the literature. The most common location of such a third molar in the mandible is in the ascending ramus.

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Aim Of The Study: Oral leukoplakia (OL) is the most common potentially malignant disorder that may transform into oral carcinoma. By treating leukoplakia in its incipient stage, the risk of occurrence of oral carcinoma can be prevented. In this aspect, photodynamic therapy (PDT) can serve as a useful treatment modality.

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Aim: Oral cancer is a major health concern in many parts of the world. Despite its low survival rates, when detected early or in the precancer stage, it can drastically increase the survival rates. This strongly supports the need for sensitive biomarkers to perk up early detection of oral cancers.

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Patients presenting with vague head and neck pain can lead to wide-ranging differential diagnosis. Elongation of styloid process (SP) should also be considered as one of the etiological factors for cervical pain radiating to jaws, pharyngodynia, and difficulty in swallowing. Symptomatic elongation of SP or mineralization of stylohyoid ligament is referred as Eagle's syndrome.

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Background: Radiation mucositis is an early effect of head and neck radiotherapy. Mucositis can cause ulcers, and patients may experience pain and dysphagia which need proper management. This study was conducted in 60 patients with oral malignancy.

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Aims: To assess the diagnostic accuracy of color doppler ultrasonography (CDUS) in differentiating metastatic from reactive lymph nodes in oral cancer patients.

Material And Methods: Study comprised 80 adult subjects with oral cancer, divided in two groups based on clinical criteria. Group I included 40 patients with clinically suspected metastatic cervical lymph nodes, Group II included 40 patients with clinically suspected reactive cervical lymph nodes.

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Background/purpose: Oral lichen planus is an autoimmune disorder that has posed a challenge in spite of the several treatment modalities available. Here, we have proposed yet another treatment modality, photodynamic therapy, for this condition. The aim of the study was to treat patients having symptomatic oral lichen planus with photodynamic therapy with methylene blue as photosensitizer.

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Native fluorescence spectroscopy has shown potential to characterize and diagnose oral malignancy. We aim at extending the native fluorescence spectroscopy technique to characterize normal and oral submucous fibrosis (OSF) patients under pre- and post-treated conditions, and verify whether this method could also be considered in the monitoring of therapeutic prognosis noninvasively. In this study, 28 normal subjects and 28 clinically proven cases of OSF in the age group of 20 to 40 years are diagnosed using native fluorescence spectroscopy.

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