Erratum to: Expression of REG Iα gene in type 2 diabetics in Pakistan.

[This corrects the article DOI: 10.1186/s13098-015-0092-6.].

Expression of REG Iα gene in type 2 diabetics in Pakistan.

Background: The escalating rate of diabetes' has prompted researchers around the world to explore for early markers. A deficit of functional β-cell mass plays a central role in the pathophysiology of type 2 diabetes. The REG (Regenerating) gene, encoding a 166 amino acid REG protein was discovered in rats and humans which is released in response to β-cells damage and play a role in their regeneration.

mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells.

We have reported earlier that murine-regenerating gene mReg2 protects MIN6 mouse insulinoma cells from ER stress and caspase-mediated apoptosis. In apoptotic cells, DNA damage is induced by the nuclear translocation of mitochondrial apoptosis-inducing factor (AIF). Here we tested the hypothesis that mReg2 may regulate Scythe and/or hsp70 which influence the nuclear import of AIF.