A bioprinted and scalable model of human tubulo-interstitial kidney fibrosis.

Chronic kidney disease (CKD) affects more than 10% of the global population. As kidney function negatively correlates with the presence of interstitial fibrosis, the development of new anti-fibrotic therapies holds promise to stabilize functional decline in CKD patients. The goal of the study was to generate a scalable bioprinted 3-dimensional kidney tubulo-interstitial disease model of kidney fibrosis.

Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1/NKX6.1 progenitors.

Aims/hypothesis: Homozygous mutations in RFX6 lead to neonatal diabetes accompanied by a hypoplastic pancreas, whereas heterozygous mutations cause MODY. Recent studies have also shown RFX6 variants to be linked with type 2 diabetes. Despite RFX6's known function in islet development, its specific role in diabetes pathogenesis remains unclear.

A descriptive study of frequency of short term complications in late preterm neonates at a tertiary care hospital Rawalpindi.

Objective: To determine the frequency of short-term complications in late preterm neonates in a tertiary care setting.

Methods: The observational study was conducted at Benazir Bhutto Hospital, Rawalpindi, Pakistan, from December 1, 2020, to May 31, 2021, and comprised late preterm neonates. Frequency of complications were noted in the subjects.

Transcriptome Analysis of Host Inflammatory Responses to the Ectoparasitic Mite var. .

Scabies, a human skin infestation caused by the ectoparasitic mite var. , affects more than 200 million people globally. The prevailing knowledge of the disease process and host immune response mechanisms is limited.

A Computational Systems Analyses to Identify Biomarkers and Mechanistic Link in Psoriasis and Cutaneous Squamous Cell Carcinoma.

Psoriasis is the most common and chronic skin disease that affects individuals from every age group. The rate of psoriasis is increasing over the time in both developed and developing countries. Studies have revealed the possibility of association of psoriasis with skin cancers, particularly non-melanoma skin cancers (NMSC), which, include basal cell carcinoma and cutaneous squamous cell carcinoma (cSCC).