Publications by authors named "Sadaf Farsi"
Article Synopsis
- PRMT5 is identified as a key regulator of CD4+ T follicular helper (Tfh) cell responses during influenza virus infection in mice.
- Deleting PRMT5 in T cells significantly impairs Tfh and T follicular regulatory populations, leading to decreased B cell activation and lower production of influenza-specific antibodies.
- The study suggests that elevated IL-2Rα expression on PRMT5-deficient T cells may disrupt Tfh differentiation, highlighting a potential link between PRMT5 function and IL-2 signaling.
