Publications by authors named "Sadaf Farooqui"

Background: Patients diagnosed with acute myeloid leukemia (AML) face a heightened susceptibility to infections, which significantly elevates their risk of mortality and disability. The intensity of the chemotherapy treatment and its specific focus on inhibiting myeloid cell divisions render patients especially vulnerable, particularly during the early stages of chemotherapy. This vulnerability is compounded by the occurrence of repeated episodes of prolonged neutropenia, leaving patients highly susceptible to infections.

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Article Synopsis
  • Researchers developed chitosan nanoparticles (CS NPs) loaded with -allyl-l-cysteine (SC) to improve its delivery to the brain for treating ischemic conditions in rats.
  • The optimal CS NPs had a particle size of 93.21 nm, high entrapment efficiency (82.61%), and effective drug release, showing significant improvements in neurobehavioral and biochemical outcomes in rats.
  • The study demonstrated that intranasal delivery of SC via these nanoparticles significantly enhanced its brain bioavailability and neuroprotective effects, suggesting a promising treatment strategy for ischemic brain injury.
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