Enhanced antibacterial and genoprotective properties of nanoliposomal L. essential oil.

Nanoliposomes are drug delivery systems that improve bioavailability by encapsulating therapeutic agents. The main objective of this study was to investigate the effects of nanoliposomal (NL) formulation on enhancing the bioavailability of essential oil. The essential oil of (SHO) was encapsulated in nanoliposomes (SHNLs).

Comparison of Candida colonization in intensive care unit patients with and without COVID-19: First prospective cohort study from Turkey.

Candida species are the primary cause of fungal infections in intensive care units (ICUs). Despite the increasing prevalence of Candida-related infections, monitoring the progression of these infections from colonization in COVID-19 ICU patients lacks sufficient information. This study aims prospectively to compare 62 COVID-19 and 60 non-COVID-19 ICU patients from admission to discharge in terms of colonization development, rates, isolated Candida species, risk factors, and Candida infections during hospitalization.

Detection and characterization of the biofilm on the traditionally produced homemade apple vinegar.

yeasts are capable of forming biofilms during vinegar production and causing spoilage in various beverages. In addition, there exists a significant likelihood of encountering yeast contamination which can prevent vinegar production. The present study investigates the detection and characterization of the () biofilm on traditionally produced homemade apple vinegar.

Synthesis and Anticancer and Antimicrobial Evaluation of Novel Ether-linked Derivatives of Ornidazole.

Objectives: Some novel 1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-(substituted phenoxy)propan-2-ol derivatives were designed and synthesized.

Materials And Methods: Compounds were obtained by refluxing ornidazole with the corresponding phenolic compounds in the presence of anhydrous KCO in acetonitrile.

Results: Following the structure elucidation, the antimicrobial activity and cytotoxic effects of compounds on K562 leukemia and NIH/3T3 mouse embryonic fibroblast cells were measured.

Antibacterial and photodynamic effects of some plant extracts for cavity disinfection.

Background: In current dental treatments, with the aim of a preventive approach,it is argued that removing only the infected layer of dentin is sufficient for cavity preparation. However it is impossible to be sure that the infected layer was completely removed. In addition, the cause of secondary caries and post operative sensitivities has been reported as residual bacteria in some studies.

Determination of antimicrobial and antiviral properties of IR3535.

Insect repellent is a substance directly applied to skin or clothing in order to repel flies, mosquitoes, ticks etc. IR3535 or Ethyl butylacetylaminopropionate (EBAAP) is a relatively new repellent which is classified as a biopesticide due to exceptional skin tolerance and overall safety. The repellency against various insect and ticks, and the low toxicity of IR3535 are well acknowledged.

Design, Synthesis, and Molecular Docking Studies of a Conjugated Thiadiazole-Thiourea Scaffold as Antituberculosis Agents.

In view of the emergence and frequency of multidrug-resistant and extensively drug-resistant tuberculosis and consequences of acquired resistance to clinically used drugs, we undertook the design and synthesis of novel prototypes that possess the advantage of the two pharmacophores of thiourea and 1,3,4-thiadiazole in a single molecular backbone. Three compounds from our series were distinguished from the others by their promising activity profiles against Mycobacterium tuberculosis strain H37Rv. Compounds 11 and 19 were the most active representatives with minimum inhibitory concentration (MIC) values of 10.

Evaluation of Antimicrobial and Antiviral Activities of Different Venoms.

Background: Animals' venomous secretions or peptides obtained from those secretions are used in the development of new therapeutic agents. The aims of this study were to investigate antimicrobial and antiviral activity of four different venoms obtained from the frog named Bufo arenarum and the snakes Crotalus atrox, Causus rhombeatus and Naja melanoleuca.

Methods: Antimicrobial activities of the venoms tested against 9 bacteria, 1 yeast, 1 fungal species and 2 viral species based on micro-well dilution assay and antiviral assay.

Determination of antimicrobial properties of picaridin and DEET against a broad range of microorganisms.

Insect repellents are topically applied to the skin and clothing of human and pet to keep flies, mosquitoes, and ticks away. Two important repellents, N,N-diethyl-meta-toluamide (DEET) and Picaridin, have been widely used since their discovery. Although repellency and toxicological effects of DEET and Picaridin on human being and insects are well documented without understanding molecular mechanisms, there have been no attempts to study their effects on microorganisms up to now.