Design, development and evaluation of chronomodulated drug delivery systems of amoxicillin trihydrate with enhanced antimicrobial activity.

The present studies entail the formulation development and evaluation of chronomodulated drug delivery system of amoxicillin trihydrate (AMT), which comprises of a bilayer tablet containing a delayed release and a sustained release layer. Direct compression method was employed for the preparation of bilayer matrix tablets containing rational blend of polymers, such as Eudragit-L100 D55 as delayed release polymer and HPMCK4M, HPMCK15 and HPMCK100 are sustained release polymers. In- vitro drug release studies of bilayer tablets observed a good sustained release action with time-dependent burst release after a lag-time of 3 hrs.

Enhanced antimalarial activity of lumefantrine nanopowder prepared by wet-milling DYNO MILL technique.

Lumefantrine (LMF) is an antimalarial drug that exhibits poor oral bioavailability, owing to its poor aqueous solubility. To improve its antimalarial activity, nanopowder formulation using DYNO MILL was prepared. Combination of HPMC E3 (4%, w/v) and Tween 80 (2.

Enhanced bioavailability of nano-sized chitosan-atorvastatin conjugate after oral administration to rats.

A novel approach to improve the bioavailability and stability of atorvastatin (AT) was developed by constructing a nano-sized polymer-atorvastatin conjugate. Firstly, a novel chitosan-atorvastatin (CH-AT) conjugate was efficiently synthesized through amide coupling reaction. The formation of conjugate was confirmed by (1)H NMR and FT-IR spectrometry.