Publications by authors named "Sachin Deorukhkar"
Medical Device-Associated Candida Infections in a Rural Tertiary Care Teaching Hospital of India.
Interdiscip Perspect Infect Dis
February 2016
Health care associated infections (HCAIs) add incrementally to the morbidity, mortality, and cost expected of the patient's underlying diseases alone. Approximately, about half all cases of HCAIs are associated with medical devices. As Candida medical device-associated infection is highly drug resistant and can lead to serious life-threatening complications, there is a need of continuous surveillance of these infections to initiate preventive and corrective measures.
View Article and Find Full Text PDFEchinocandin Susceptibility Profile of Fluconazole Resistant Candida Species Isolated from Blood Stream Infections.
Infect Disord Drug Targets
February 2017
Background: Over the last two decades, Candida blood stream infections (BSIs) have been increasingly reported from various parts of the world. Recent studies on invasive candidiasis have documented the emergence of non albicans Candida (NAC) species as major pathogens. Candida spp.
View Article and Find Full Text PDFArticle Synopsis
- Infectious diseases have evolved significantly, with fungi previously seen as harmless now recognized as major threats, especially in immunocompromised patients.
- Among fungal pathogens, Candida spp. are prevalent, with a notable shift from Candida albicans to non-albicans species, which show lower responses to common antifungal treatments.
- The study analyzed 523 Candida isolates, revealing that non-albicans species are the main pathogens, exhibiting virulence factors and high resistance to azole antifungals, indicating their growing importance in clinical infections.
The incidence of invasive candidiasis has increased over the past few decades. Although Candida albicans remains by far the most common species encountered, in recent years shift towards non-albicans Candida species like Candida tropicalis is noted. Here in this study we determined the virulence factors and antifungal susceptibility profile of 125 C.
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- The study investigated the patterns and risk factors of corneal ulcers in rural western Maharashtra, India, focusing on the agents causing keratitis.
- A total of 852 patients were analyzed, with 63.02% testing positive for infections, predominantly affecting farmers, and ocular trauma being the leading risk factor.
- Fungal infections (57.91%) were more common than bacterial ones (42.08%), with Fusarium spp. as the most frequent fungal isolate and Streptococcus pneumoniae as the most common bacterial isolate.