Publications by authors named "Sachin C Deorukhkar"

Health care associated infections (HCAIs) add incrementally to the morbidity, mortality, and cost expected of the patient's underlying diseases alone. Approximately, about half all cases of HCAIs are associated with medical devices. As Candida medical device-associated infection is highly drug resistant and can lead to serious life-threatening complications, there is a need of continuous surveillance of these infections to initiate preventive and corrective measures.

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Background: Over the last two decades, Candida blood stream infections (BSIs) have been increasingly reported from various parts of the world. Recent studies on invasive candidiasis have documented the emergence of non albicans Candida (NAC) species as major pathogens. Candida spp.

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Article Synopsis
  • Infectious diseases have evolved significantly, with fungi previously seen as harmless now recognized as major threats, especially in immunocompromised patients.
  • Among fungal pathogens, Candida spp. are prevalent, with a notable shift from Candida albicans to non-albicans species, which show lower responses to common antifungal treatments.
  • The study analyzed 523 Candida isolates, revealing that non-albicans species are the main pathogens, exhibiting virulence factors and high resistance to azole antifungals, indicating their growing importance in clinical infections.
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The incidence of invasive candidiasis has increased over the past few decades. Although Candida albicans remains by far the most common species encountered, in recent years shift towards non-albicans Candida species like Candida tropicalis is noted. Here in this study we determined the virulence factors and antifungal susceptibility profile of 125 C.

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