Publications by authors named "Sacheera Angulmaduwa"
Article Synopsis
- The study examines the role of phase variation in the oipA gene of Helicobacter pylori, which is associated with IL-8 induction and gastric inflammation, in the context of H. pylori's overall virulence and potential links to gastric cancer.
- Using two different strains, the research differentiates between natural and in vitro-induced phase variations of the oipA gene, discovering that while natural variations don’t significantly impact IL-8 induction or cell elongation, in vitro changes do show effects on cell morphology.
- The findings highlight the complexity of genetic interactions influencing the virulence of H. pylori, suggesting that oipA phase variation plays a crucial, yet nuanced role in bacterial pathogenicity and warrants further investigation into
The polymorphic bacterial oncoprotein, CagA shows geography-dependent variation in the C-terminal Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs; East-Asian H. pylori isolates carry the ABD type while Western isolates carry the ABC type. In Western isolates, the EPIYA-C motif is sometimes found in multi-copy and this genotype is associated with disease severity.
View Article and Find Full Text PDFBackground: Antibiotic Resistance is an imminent global public health threat. Antibiotic resistance emerged in healthcare settings and has now moved on to the community settings. This study was conducted to identify the rates of asymptomatic colonization with selected antibiotic resistant organisms, (Methicillin Resistant Staphylococcus aureus (MRSA), Extended Spectrum Beta Lactamase (ESBL) producing Escherichia coli and Klebsiella spp and carbapenem resistant E.
View Article and Find Full Text PDFBackground: Streptococcus pneumoniae continues to cause mortality and morbidity despite availability of effective vaccines. Pneumococcal colonization is considered a pre-requisite for disease. Identifying the serotypes circulating in a given locale is important for surveillance purposes as well as for assessing the need for vaccination.
View Article and Find Full Text PDFObjectives: Nurses are the main communication link for healthcare messages to hospitalized patients and also play a crucial role in preventing the emergence and spread antibiotic resistant bacteria through antibiotic stewardship and infection control programmes. This requires them to possess correct knowledge and attitudes towards antibiotic use and resistance. This study was carried out to identify the level of knowledge, attitude and practices on antibiotic use and antibiotic resistance among student nurses.
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