Epidemiology of Angina Bullosa Hemorrhagica: A Retrospective study.

Introduction: Angina Bullosa Hemorrhagica (ABH) is a rare condition characterized by hemorrhagic blisters and is often asymptomatic. These lesions appear more commonly in the oral cavity and oropharynx and are often misdiagnosed. A retrospective cross-sectional study was performed in clinically confirmed cases of ABH to study its epidemiology, etiology and presentation in a tertiary care hospital in Southern Asia.

Association of iron deficiency and anemia with obesity among children: A systematic review and meta-analysis.

Introduction: Obesity is a potential risk factor for anemia in children. This systematic review (SR) was undertaken to estimate the association of obesity with iron deficiency (ID) and ID anemia (IDA), in children.

Methods: A systematic literature search for observational studies was done in PubMed, EMBASE, Scopus, and the Cochrane library, with additional hand-searching.

Interplay of canonical and LIMK mediated non-canonical BMP signaling is essential for regulating differential thickness and invagination during chick forebrain roof plate morphogenesis.

Telencephalic hemisphere formation is a complex and precisely timed process, which begins in the chick forebrain with an invagination in the middle of the roof plate. However, the factor(s) that determine the position/site of invagination in the roof plate remain to be elucidated. In this study, we have demonstrated that as development proceeds, a region of lower thickness appears in the middle of the roof plate, which marks the position where the invagination begins.

Development of Stabilized and Aqueous Dissolvable Nanosuspension Encompassing BCS Class IV Drug via Optimization of Process and Formulation Variables.

Background: Nanosuspension has emerged as an effective, lucrative, and unequalled approach for efficiently elevating the dissolution and bioavailability of aqueous soluble drugs. Diverse challenges persist within this domain, demanding further comprehensive investigation and exploration.

Objective: This study aims to design, develop, optimise formulation and process variables, and characterise the stabilised aqueous dissolvable nanosuspension using chlorthalidone as a BCS class- IV drug.

Second trimester medical abortion in acute promyelocytic leukaemia.

Acute promyelocytic leukaemia (APL) is a highly lethal haematological malignancy. It is rare in pregnancy and may be fatal if not managed promptly and appropriately. A woman in her 20s presented with high-grade fever at 16 weeks of her third pregnancy.

From teeth to ethnicity: A neural network approach to predicting population of origin through dental traits and anomalies.

Background: This study aimed to investigate the prevalence of dental traits and anomalies in five North Indian populations (Khas Bodhi, Jaat, Khatri, Garhwali, and Gujjar) and predict the population of origin based on these traits and anomalies for forensic applications.

Methods: We assessed dental traits and anomalies in 454 individuals through intraoral examination. Neural network analysis was employed to predict the population of origin based on a combination of dental traits and anomalies.

Unveiling the Neurotransmitter Symphony: Dynamic Shifts in Neurotransmitter Levels during Menstruation.

The menstrual cycle is an intricate biological process governed by hormonal changes that affect different facets of a woman's reproductive system. This review provides an overview of neurotransmitter alterations during different menstrual cycle phases and their effects on physiology and psychology. During the follicular phase, rising estrogen levels increase serotonin synthesis, enhancing mood, cognition, and pain tolerance.

CsPbBr-PbSe Perovskite-Chalcogenide Epitaxial Nanocrystal Heterostructures and Their Charge Carrier Dynamics.

Lead halide perovskite and chalcogenide heterostructures which share the ionic and covalent interface bonding may be the possible materials in bringing phase stability to these emerging perovskite nanocrystals. However, in spite of significant successes in the development of halide perovskite nanocrystals, their epitaxial heterostructures with appropriate chalcogenide nanomaterials have largely remained unexplored. Keeping the importance of these materials in mind, herein, epitaxial nanocrystal heterostructures of CsPbBr-PbSe are reported.

Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance.

Alzheimer's disease (AD) is a leading cause of cognitive decline in the aging population, presenting a critical need for early diagnosis and effective prognostic tools. Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, have emerged as promising biomarkers for AD due to their roles in regulating gene expression and potential for reversibility. This review examines the current landscape of epigenetic biomarkers in AD, emphasizing their diagnostic and prognostic relevance.

Clinicopathological and Immunophenotypic Characteristics of Series of Re-arranged Acute Leukemias.

Rearrangement involving gene (-r) is recently being described in acute leukemias. We present the clinic-pathological and immunophenotypic findings in a series of five cases of acute leukemia with -r reported in our Institute between September 2020 to September 2023. Notably, while fusion was the most frequently encountered abnormality, the fusion partner was not identified in two patients with -r BCP-ALL.

Prognostic Significance of Regulatory T-Cells and PD-1 + CD8 T-Cells in Chronic Myeloid Leukemia Patients Treated with Generic Imatinib.

The impact of T-regulatory cells (Tregs), PD-1 + CD8 T-cells, and their dynamics during treatment with imatinib mesylate remains poorly understood in patients with chronic myeloid leukemia (CML). We conducted a prospective study on newly diagnosed, treatment-naïve adult (> 18 years old) patients with CML in the chronic phase (CP) and age- and sex-matched controls. Peripheral blood samples were collected at diagnosis and after three months of imatinib therapy to assess Tregs and PD-1 + CD8 T-cell levels using flow cytometry.

Identification of Middle Mesial Canal in Mandibular Molars Using Five Different Techniques: An Study.

Aim: The purpose of the study was to find out the incidence of the middle mesial canal in mandibular molars by using five different techniques.

Materials And Methods: A total of 150 extracted human mandibular first molars were selected, and cone beam computed tomography (CBCT) images were taken. Then, conventional access cavities were made, followed by troughing under dental loupes (3X), and were also examined under a dental operating microscope (DOM) (6X).

Current developments and advancements of 3-dimensional printing in personalized medication and drug screening.

Introduction: 3-Dimensional printing (3DP) is an additive manufacturing (AM) technique that is expanding quickly because of its low cost and excellent efficiency. The 3D printing industry grew by 19.5 % in 2021 in spite of the COVID-19 epidemic, and by 2026, the worldwide market is expected to be valued up to 37.

The Battle of Endoscopic Bariatric Therapies for Obesity: Endoscopic Sleeve Gastroplasty Versus Endoscopically Inserted Intragastric Balloon-A Pairwise Meta-Analysis of Comparative Studies and a Call for Randomized Controlled Trials.

Background: Endoscopic sleeve gastroplasty (ESG) represents the latest primary endoscopic intervention for managing obesity. Both ESG and intragastric balloons (IGBs) have demonstrated effectiveness and safety for weight loss. However, there is a paucity of high-quality evidence supporting the superiority of one over the other, and no pairwise meta-analysis of comparative studies has been published to date.

Ultrafast Interfacial Charge Transfer in Anisotropic One-Dimensional CsPbBr/Pt Epitaxial Heterostructure.

Colloidal one-dimensional (1D) perovskite nanorods (NRs) and metal epitaxial heterostructures (HSs) are the promising class of new materials for efficient photovoltaic and photocatalytic applications. Besides, fundamental photophysical properties and its device applications of 1D perovskite-metal HSs are limited due to their challenging synthetic protocols and difficulties in forming epitaxial growth between covalent and ionic bonds. Herein, we have synthesized the CsPbBr perovskite NRs-platinum (Pt) nanoparticles (NPs) (CsPbBr/Pt) epitaxial HS using cation exchange followed by chemical reduction methods with the orthorhombic CsCuBr NRs.