Publications by authors named "Sacchelli L"
Pityriasis rubra pilaris (PRP) presents a diagnostic challenge due to its varied clinical manifestations and the scarce literature on scalp involvement. This article presents a case report of a 59-year-old female with PRP solely affecting the scalp, detailing its clinical, trichoscopic, and histopathological features. Trichoscopy revealed a novel finding of white-silvery scales forming hair casts with a triangular shape, distinct from the existing literature.
View Article and Find Full Text PDFArticle Synopsis
- Skin infections can be linked to underlying diseases, with lymphomas being a potential primary cause.
- There are two types of lymphomas related to the skin: primary cutaneous lymphoma and secondary cutaneous lymphoma (SCL), the latter being associated with systemic lymphoma.
- The review aims to explore current knowledge about SCL, focusing on clinical aspects, histological characteristics, and survival rates.
Background: Psoriasis (P) and atopic dermatitis (AD) share some common characteristics. The resulting clinical picture with shared manifestations is a new entity called psoriasis dermatitis (PD), atopic psoriasis or psorema. The purpose of this study was to identify the clinical manifestations of this new dermatological condition, focusing on the adult population.
View Article and Find Full Text PDFArticle Synopsis
- - Humoral immunity, which relies on antibodies, struggles against SARS-CoV-2 mutants, while CD8 T cells show more resistance to mutation effects.
- - Analysis of spike variant peptides reveals that mutations can either inhibit or enhance CD8 T cell responses in vaccinated and recovered individuals.
- - The emergence of new T cell function enhancing epitopes may improve antiviral protection and inform the future development of more effective COVID-19 vaccines.
Article Synopsis
- Polyclonal free light chains (FLCs) of immunoglobulins are important indicators of immune system activity and dysfunction, particularly in patients with psoriasis.
- A study involving 45 psoriasis patients showed that those receiving biological treatment had significantly higher levels of FLCs compared to healthy individuals, with levels correlating to the duration of therapy.
- The findings suggest that measuring FLC levels could be clinically useful for monitoring immune reactivation in psoriatic patients on biologic treatments, offering a cost-effective method for improving patient management.
Reply to "Dermatoses caused by face mask wearing during the COVID-19 pandemic".
J Eur Acad Dermatol Venereol
June 2022
Background: Palmoplantar psoriasis is difficult to treat and often recalcitrant to conventional therapies. Clinical trials have demonstrated the efficacy and safety of secukinumab for this debilitating psoriasis form, but real-life evidence is currently limited. Therefore, here we described the outcomes of patients treated with secukinumab in clinical practice.
View Article and Find Full Text PDFPsoriasis is a chronic inflammatory dermatosis affecting 2%-3% of the general population. The link between psoriasis and renal dysfunction has been investigated, demonstrating a common pro-inflammatory pathogenesis. This study is aimed at evaluating renal function in patients with moderate-to-severe chronic plaque psoriasis treated with biological therapy.
View Article and Find Full Text PDF