Background: Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) share clinical, pathological, immunohistochemical and molecular features, though PDS is associated with a more aggressive behavior.
Methods: We reviewed 71 tumors fulfilling criteria for AFX and PDS to further stratify their biological potential.
Results: Lesions were mainly located on the scalps of elderly men, and were often ulcerated.