Publications by authors named "Sabrina Mendez"
Background: Lipid reprogramming is a known mechanism to increase the energetic demands of proliferating cancer cells to drive and support tumorigenesis and progression. Elevated lipid droplets (LDs) are a well-known alteration of lipid reprogramming in many cancers, including prostate cancer (PCa), and are associated with high tumor aggressiveness as well as therapy resistance. The mechanism of LD accumulation and specific LD functions are still not well understood; however, it has been shown that LDs can form as a protective mechanism against lipotoxicity and lipid peroxidation in the cell.
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- The prostate cancer tumor microenvironment (TME) contains various cell types, including macrophages that can be M1-like (anti-tumor) or M2-like (pro-tumor), with M2 macrophages playing a key role in efferocytosis, the process of engulfing dying cells.
- Research suggests that targeting MerTK, a receptor involved in efferocytosis, may hinder tumor growth and enhance anti-tumor immune responses.
- Initial findings from experiments show that M2 macrophages have a higher capacity for efferocytosis of prostate cancer cells and that inhibiting MerTK reduces this process, promoting a shift toward a more anti-tumor immune profile in a mouse model.
This work aims to study the testicular morphology and spermatogenesis of Gymnotus carapo to provide information on their reproductive biology which is useful in managing this species as a fishing resource. The testicles were isolated and fixed in 10% formalin; subsequently, they were processed for scanning electron microscopy with conventional histological technique. To analyze the cell proliferation of germline cells and Sertoli cells, immunodetection of the proliferating cell nuclear antigen (PCNA) protein was performed.
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