Publications by authors named "Sabrina Markert"
Article Synopsis
- Tissue macrophages are crucial for maintaining organ function, immune responses, and the development of inflammation-driven diseases, but studying them in complex organs like the kidney has been challenging.
- Researchers developed a new type of mouse model called c-fms-eGFP-L10a transgenic mice (Mac), which allows for targeted study of macrophages by expressing a fluorescent marker specifically in these cells.
- The study successfully isolated and sequenced macrophage-specific RNA from the kidneys of these mice, revealing unique gene expression patterns and offering a promising new tool for exploring macrophage biology in various health and disease scenarios.
Ca(2+)-activated K(+) channels (KCa) play a pivotal role in the endothelium-dependent hyperpolarization and regulation of vascular tone and blood pressure. For activation, KCa depend on an increase of intracellular calcium which is substantially mediated by Ca(2+)-permeable cation channels including the transient receptor potential V4 (TRPV4). It has been proposed that KCa and Ca(2+)-permeable cation channels may be clustered in localized positions within the cell membrane to form functional units and that caveolae may constitute the scaffolding for such microcompartmental organization.
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