Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to Cu-Induced Oxidation .

Lycopene-based medications and supplements have been developed to prevent atherosclerosis, primarily because of their ability to decrease low-density lipoprotein (LDL) oxidation. Bixin and norbixin are carotenoids found in the seeds of annatto () and are colorants widely used by the food industry. Some studies have already demonstrated that these compounds have antioxidant and antiatherogenic potential and in animal models, but there is no evidence supporting the effects of their long-term or short-term consumption by humans.