Publications by authors named "Sabrina L Levy"
Hypothesis: A terra cotta plaque [LMU 2551] from the Neo-Babylonian period (c.629-539 BCE), housed in the museum of the Archaeology Center at Loyola Marymount University, Los Angeles, is a representation of right peripheral facial paralysis.
Background: Ancient representations of pathology are rare and often difficult to identify.
Background and Purpose- Many restorative therapies have been used to study brain repair after stroke. These therapeutic-induced changes have revealed important insights on brain repair and recovery mechanisms; however, the intrinsic changes that occur in spontaneously recovery after stroke is less clear. The goal of this study is to elucidate the intrinsic changes in spontaneous recovery after stroke, by directly investigating the transcriptome of primary motor cortex in mice that naturally recovered after stroke.
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- Anatomical labeling techniques are crucial for understanding how the brain is organized, with tract tracing being key for studying neuronal pathways.
- One major challenge in these studies is achieving good visibility to differentiate between closely neighboring neuronal pathways.
- This text highlights the use of wheat germ agglutinin (WGA) conjugated to Alexa fluorophores for high-resolution tracing in the mouse cerebellum, which helps in mapping motor function circuits and marking specific brain regions.
Synaptic connections undergo activity-dependent plasticity during development and learning, as well as homeostatic re-adjustment to ensure stability. Little is known about the relationship between these processes, particularly in vivo. We addressed this with novel quantal resolution imaging of transmission during locomotive behavior at glutamatergic synapses of the Drosophila larval neuromuscular junction.
View Article and Find Full Text PDFStroke is one of the leading contributors to morbidity, mortality, and health care costs in the United States. Although several preclinical strategies have shown promise in the laboratory, few have succeeded in the clinical setting. Optogenetics represents a promising molecular tool, which enables highly specific circuit-level neuromodulation.
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- Cerebellar circuits are organized into topographic zones that are essential for motor coordination and learning, and disruptions in these zones are linked to neurological diseases.
- The study focuses on Purkinje cells and their role in developing and refining these cerebellar zones, using conditional mouse genetics to investigate their neurotransmission.
- Findings indicate that Purkinje cell inhibitory neurotransmission is crucial for proper zone patterning, affecting the circuitry and firing patterns in cerebellar neurons, and its loss leads to ataxia and abnormal molecular expression in Purkinje cells.