Survival advantage of women in localized melanoma mainly relies on clinical-pathological differences by sex. A retrospective study of 1,607 patients in Valencia, Spain.

Background: Among melanoma patients, women have a better prognosis than men but the differences might be due to a different presentation of melanoma.

Objectives: The aim of this study was to identify differences in clinical presentation and survival in cutaneous melanoma between men and women in a Spanish population stratified by age.

Materials & Methods: In total, 1,607 consecutive patients with localized cutaneous melanoma and complete clinical and pathological information were evaluated.

High immunohistochemical nestin expression is associated with greater depth of infiltration in dermatofibrosarcoma protuberans: a study of 71 cases.

Background: Dermatofibrosarcoma protuberans (DFSP) was recently shown to express nestin, a marker that has been associated with poorer prognosis when present in high levels in certain tumors. The objective of this study is to explore the association between high nestin expression and deep invasion.

Methods: We performed a retrospective, observational study in which we evaluated the degree of nestin expression in 71 DFSP.