Publications by authors named "Sabrina Grenetier"
The gene vestigial (vg) plays a key role in indirect flight muscle (IFM) development. We show here that vg is controlled by the Notch anti-myogenic signaling pathway in myoblasts and is regulated by a novel 822 bp enhancer during IFM differentiation. Interestingly, this muscle enhancer is activated in developing fibers and in a small number of myoblasts before the fusion of myoblasts with the developing muscle fibers.
View Article and Find Full Text PDFCTD kinase I is required for the integrity of the rDNA tandem array.
Nucleic Acids Res
November 2006
Article Synopsis
- The genomic stability of the rDNA tandem array is essential for maintaining repeat sequences and preventing harmful changes, and the absence of the CTD kinase I (CTDK-I) complex in yeast leads to a reduction in rDNA repeats.
- Reintroducing the CTDK-I complex helps restore rDNA repeat numbers, with the expansion of these repeats relying on the protein Fob1, while its absence causes contraction of these repeats.
- The study suggests that defects in RNA polymerase I transcription caused by mutations in the kinase subunit Ctk1 can lead to the loss of rDNA repeats, although the silencing of certain rDNA class II genes remains unaffected.
RNA polymerase II carboxy terminal domain (CTD) kinases are key elements in the control of mRNA synthesis. Yeast CTD kinase I (CTDK-I), is a non-essential complex involved in the regulation of mRNA synthesis at the level of transcription elongation, pre-mRNA 3' formation and nuclear export. Here, we report that CTDK-I is also involved in ribosomal RNA synthesis.
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