Publications by authors named "Sabrina Eugster"
Drug sensitivity and resistance testing on diagnostic leukemia samples should provide important functional information to guide actionable target and biomarker discovery. We provide proof of concept data by profiling 60 drugs on 68 acute lymphoblastic leukemia (ALL) samples mostly from resistant disease in cocultures of bone marrow stromal cells. Patient-derived xenografts retained the original pattern of mutations found in the matched patient material.
View Article and Find Full Text PDFArticle Synopsis
- TCF3-HLF-positive acute lymphoblastic leukemia (ALL) is a serious disease that is currently very hard to cure.
- Researchers found unique changes in the genes and drug reactions of TCF3-HLF-positive ALL compared to another type, TCF3-PBX1-positive ALL.
- They discovered that certain genetic changes in TCF3 and PAX5 help explain why TCF3-HLF ALL is tougher to treat but also found possible new treatments that could be effective.